Detailed information of TA system TA206187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 24584..25077
• Replicon: plasmid unnamed
• Accession: NZ_CP076670
• Organism: Listeria monocytogenes strain UKVDL7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KQX72_RS14735
• Protein ID: WP_068995950.1
• Coordinates: 24802..25077 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KQX72_RS14730
• Protein ID: WP_068995951.1
• Coordinates: 24584..24805 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQX72_RS14720 (KQX72_14720)	21031..22173	+	1143	WP_216697862.1	hypothetical protein	-
KQX72_RS14725 (KQX72_14725)	22177..24501	+	2325	WP_216697863.1	type IV secretory system conjugative DNA transfer family protein	-
KQX72_RS14730 (KQX72_14730)	24584..24805	+	222	WP_068995951.1	DUF6290 family protein	Antitoxin
KQX72_RS14735 (KQX72_14735)	24802..25077	+	276	WP_068995950.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQX72_RS14740 (KQX72_14740)	25313..27217	+	1905	WP_216697864.1	hypothetical protein	-
KQX72_RS14745 (KQX72_14745)	27233..27505	+	273	WP_068995947.1	DUF5592 family protein	-
KQX72_RS14750 (KQX72_14750)	27507..28046	+	540	WP_216697826.1	hypothetical protein	-
KQX72_RS14755 (KQX72_14755)	28043..29989	+	1947	WP_180680582.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..53953	53953

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-89)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10882.57 Da
• Isoelectric Point: 10.4614

>T206187 WP_068995950.1 NZ_CP076670:24802-25077 [Listeria monocytogenes]
MSKHFHVRFEKDAQKVLKKMDRFQAKLILSWIEKHIEGSDNPRQHGKSLVGNRVGQWRYRVGDYRLIAEIQDNEVIVLIL
NIGHRRDIYDK

Nucleotide

• Length: 276 bp

>T206187 NZ_CP102186:2000364-2000466 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8509.66 Da
• Isoelectric Point: 4.4929

>AT206187 WP_068995951.1 NZ_CP076670:24584-24805 [Listeria monocytogenes]
MTTITFRVSEQEKAFIQEMAKFNGISISELSRKQIIEGLEDQIDLQSYERAIKAHQVKDESISFDEMKKELDL

Nucleotide

• Length: 222 bp

>AT206187 NZ_CP102186:c2000473-2000328 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT