Detailed information of TA system TA206183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 828709..829748
• Replicon: chromosome
• Accession: NZ_CP076668
• Organism: Pseudomonas lijiangensis strain LJ2

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: KQP88_RS03610
• Protein ID: WP_216704878.1
• Coordinates: 828709..829284 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: KQP88_RS03615
• Protein ID: WP_216705880.1
• Coordinates: 829281..829748 (-)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQP88_RS03580 (KQP88_03580)	823895..824137	+	243	WP_216704873.1	general stress protein	-
KQP88_RS03585 (KQP88_03585)	824297..824800	-	504	WP_216704874.1	GAF domain-containing protein	-
KQP88_RS03590 (KQP88_03590)	825159..825956	+	798	WP_216704875.1	hypothetical protein	-
KQP88_RS03595 (KQP88_03595)	826087..826446	+	360	WP_198726242.1	I78 family peptidase inhibitor	-
KQP88_RS03600 (KQP88_03600)	826472..827563	-	1092	WP_216704876.1	tartrate dehydrogenase	-
KQP88_RS03605 (KQP88_03605)	827651..828568	+	918	WP_253950544.1	LysR family transcriptional regulator	-
KQP88_RS03610 (KQP88_03610)	828709..829284	-	576	WP_216704878.1	PIN domain-containing protein	Toxin
KQP88_RS03615 (KQP88_03615)	829281..829748	-	468	WP_216705880.1	helix-turn-helix domain-containing protein	Antitoxin
KQP88_RS03620 (KQP88_03620)	830111..831121	+	1011	WP_216704879.1	PDDEXK nuclease domain-containing protein	-
KQP88_RS03625 (KQP88_03625)	831171..831395	-	225	WP_253950545.1	DUF3077 domain-containing protein	-
KQP88_RS03630 (KQP88_03630)	831947..832240	-	294	WP_253950546.1	ATP-binding protein	-
KQP88_RS03635 (KQP88_03635)	832496..832744	-	249	WP_216704880.1	hypothetical protein	-
KQP88_RS03640 (KQP88_03640)	833232..834302	-	1071	WP_216704881.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	828709..840457	11748

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-132)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21750.96 Da
• Isoelectric Point: 5.0611

>T206183 WP_216704878.1 NZ_CP076668:c829284-828709 [Pseudomonas lijiangensis]
MRHSPFTAFYDANVLYPAPLRDFLMHLALSGVYRARCSAQIHEEWKRNLLINRPELTREQLDRTAALMDKAVPDALVMDY
EPLIEGLTLPDTDDRHVLAAAIKCNASVIVTFNLKDFPKSALEAFDIEPLHPDDFIADLWDLDQAAVLEAAQRQRASLKN
PPHSARQYLDKLLQQQLPETVKLLSGFEFLI

Nucleotide

• Length: 576 bp

>T206183 NZ_CP102186:330511-330879 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17083.58 Da
• Isoelectric Point: 5.0286

>AT206183 WP_216705880.1 NZ_CP076668:c829748-829281 [Pseudomonas lijiangensis]
MTTVGLTRTVLPDEKEIAAAVASSRQLAAFLSTKCETQCIELIDDTQQREVVELPTFALRLLGEILSELALGNAVKVVPI
HAELTTQEGADMLNVSRPHLVKLLDQGALPHTKTGRHRRIKFADLMAYKEQRDQASRDAMDELAAQAQELGMGYE

Nucleotide

• Length: 468 bp

>AT206183 NZ_CP102186:330293-330514 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA