Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1824136..1824650 Replicon chromosome
Accession NZ_CP076660
Organism Staphylococcus aureus strain SG511 Berlin

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag KQU62_RS09115 Protein ID WP_000581791.1
Coordinates 1824136..1824345 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag KQU62_RS09120 Protein ID WP_000138934.1
Coordinates 1824357..1824650 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQU62_RS09095 (1820025) 1820025..1821095 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
KQU62_RS09100 (1821413) 1821413..1822615 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KQU62_RS09105 (1822776) 1822776..1823459 - 684 Protein_1759 transposase -
KQU62_RS09110 (1823871) 1823871..1824008 - 138 WP_000828354.1 Lmo0850 family protein -
KQU62_RS09115 (1824136) 1824136..1824345 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
KQU62_RS09120 (1824357) 1824357..1824650 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
KQU62_RS09125 (1824816) 1824816..1826300 + 1485 WP_123090131.1 cardiolipin synthase -
KQU62_RS09130 (1826328) 1826328..1826975 + 648 WP_001187612.1 HD domain-containing protein -
KQU62_RS09135 (1827588) 1827588..1828460 - 873 WP_000725802.1 membrane protein insertase YidC -
KQU62_RS09140 (1828546) 1828546..1829187 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T206177 WP_000581791.1 NZ_CP076660:c1824345-1824136 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T206177 NZ_CP102179:4766415-4766714 [Pseudomonas canavaninivorans]
ATGACTGAGACTTTTACAGAATTCGACCCCGCAGAATACCTCAGCACTCCCGAGGCCATCGCGGAGTTCATGAGCGATGC
CCTGGAAACCGGCGACGCAAGTTATATCGCCAAAGCGATGGGCGTAGTCGCACGAGCCAAGGGGATGACCGAATTGGCCA
GGGAAACGGGCCTGTCGCGCGAACAGCTATACCGTTCCTTCAGCGAGCACGGTAATCCCACTCTAAAAACACTTCTGGCG
GTCATGAAGGCACTTGGTGTCGATATGACGGCTCGGCCACACACGCACACTGCGTCGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT206177 WP_000138934.1 NZ_CP076660:c1824650-1824357 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT206177 NZ_CP102179:4766120-4766422 [Pseudomonas canavaninivorans]
ATGAAGAAAATCGAATCCAGCAAATTCCGATCCTGGCTGAAAAAGCTCAAGGATGACACCGGCAGAGCTCGTATTACTTC
ACGGATCAATCGACTGATAGAGGGTTTACCTGGCGATGTCGCTCCAGTCGGCCATGGTCTCAGTGAGCTACGAATTCACT
ACGGGCCTGGCTACAGGGTGTACTTTTACCAGCAGGGCGATGTGCTGGTGATTCTACTCTGTGGCGGCGACAAGGGCAGT
CAGAGCCGCGACATTGAAACCGCCCACCAGATAATGCAGGCGTGGAGAGCACAAAATGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References