206171

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1607647..1608423 Replicon chromosome
Accession NZ_CP076660
Organism Staphylococcus aureus strain SG511 Berlin

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag KQU62_RS07840 Protein ID WP_000031108.1
Coordinates 1607647..1607799 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag KQU62_RS07845 Protein ID WP_001251219.1
Coordinates 1607824..1608423 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQU62_RS07825 (1603792) 1603792..1604613 + 822 WP_000669380.1 RluA family pseudouridine synthase -
KQU62_RS07830 (1605070) 1605070..1606455 - 1386 WP_000116227.1 class II fumarate hydratase -
KQU62_RS07835 (1606651) 1606651..1607046 - 396 WP_000901019.1 hypothetical protein -
KQU62_RS07840 (1607647) 1607647..1607799 - 153 WP_000031108.1 SAS053 family protein Toxin
KQU62_RS07845 (1607824) 1607824..1608423 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
KQU62_RS07850 (1608582) 1608582..1609052 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KQU62_RS07855 (1609057) 1609057..1610184 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
KQU62_RS07860 (1610335) 1610335..1611057 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
KQU62_RS07865 (1611050) 1611050..1612507 - 1458 WP_000649898.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T206171 WP_000031108.1 NZ_CP076660:c1607799-1607647 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T206171 NZ_CP102179:526778-527065 [Pseudomonas canavaninivorans]
ATGACCGAACAATTCACTCGCTGGGACTCTGCCGAGTACCTCAAGACCGAAGAGGACATGGCGAACTATTTGGATGCATG
CATGGACGAGGCAGGAGATGACCCCGCATTCATTGCTAAAGCCCTAGGGACCATTGCACGAGCTCGTGGGATGACCCAGG
TGGCCCGTGACGCGGGCCTCTCTCGGGAAAACCTTTATCGCGCCTTGTCAGGGGAAGGAAACCCTGAGTTCGGTACTATT
TTGAAAGTTGTTAAAGCGTTGGGGCTGAAACTGCATGCCAGTACCTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT206171 WP_001251219.1 NZ_CP076660:c1608423-1607824 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT206171 NZ_CP102179:526476-526781 [Pseudomonas canavaninivorans]
ATGACGGAGATCATTCGAAGCTCTACCTTTTCCGGCTGGCTCTCGAAGCTGGCTGATAGCCGTGCCAGGATGCGTATTCA
GGTTCGAGTCGATCGTATGGCCGATGGGAATCTGGGTGACGTCAAAGCTTTAGGAGAAGGGTTGAGTGAGGCCCGTATCG
ATTACGGTCCGGGCTATCGAATTTATTTCATGCAGCAAGGCCGACAATTGATCATCCTTCTGTGTGGTGGTGACAAAAGC
AGTCAAGCACGTGATATCAAGCAAGCCAGGCTGATCGCAAAATCCTGGCAGGAGCAAAACCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References