Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 548632..549109 Replicon chromosome
Accession NZ_CP076660
Organism Staphylococcus aureus strain SG511 Berlin

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KQU62_RS02775 Protein ID WP_000052076.1
Coordinates 548632..548820 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KQU62_RS02780 Protein ID WP_001059690.1
Coordinates 548849..549109 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQU62_RS02745 (544585) 544585..545142 + 558 WP_000824491.1 hypothetical protein -
KQU62_RS02750 (545483) 545483..546169 + 687 WP_001574556.1 thermonuclease family protein -
KQU62_RS02755 (546526) 546526..546726 + 201 WP_001059082.1 cold-shock protein -
KQU62_RS02760 (547223) 547223..547441 - 219 WP_000005879.1 hypothetical protein -
KQU62_RS02765 (547503) 547503..547787 - 285 WP_001004401.1 hypothetical protein -
KQU62_RS02770 (547875) 547875..548444 - 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
KQU62_RS02775 (548632) 548632..548820 - 189 WP_000052076.1 hypothetical protein Toxin
KQU62_RS02780 (548849) 548849..549109 - 261 WP_001059690.1 hypothetical protein Antitoxin
KQU62_RS02785 (549450) 549450..549653 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KQU62_RS02790 (549650) 549650..549886 - 237 WP_000368687.1 hypothetical protein -
KQU62_RS02795 (550111) 550111..550692 + 582 WP_001140696.1 histidine phosphatase family protein -
KQU62_RS02800 (550765) 550765..551382 - 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
KQU62_RS02805 (551538) 551538..552032 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KQU62_RS02810 (552431) 552431..552853 - 423 WP_123090159.1 organic hydroperoxide resistance protein -
KQU62_RS02815 (553001) 553001..553717 + 717 WP_000150022.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(5-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T206168 WP_000052076.1 NZ_CP076660:c548820-548632 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T206168 NZ_CP102177:c6079658-6079293 [Pseudomonas corrugata]
ATGAAATGGGATGTTGAATACACAGATGAGTTTGAGATTTGGTGGAACCGTCTCGGTGAGAGTGAGCAGGATTCTGTGCA
GGCCTCGGTAATGTTGCTGGGTGATGCCGGGCCTTTCTTGGGCTTTCCTCATACCAGCGATATTAAAGGTTCGCGTCATG
GCAACCTTCGGGAGCTACGGGTGCAGCATGGAGGAAGACCTTATCGTGTGCTCTATGCCTTCGACCCGCGTCGCTGCGCC
ATTCTTCTGATCGGCGGAGGCAAGACCGGCCAGGATCGCTGGTATCACGAGTACGTGCCTTTGGCCGAGCGTCTTTATGA
CGAGCATTTGGAAGTATTGAAGAAAGAGGGGTTTGACAATGGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT206168 WP_001059690.1 NZ_CP076660:c549109-548849 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT206168 NZ_CP102177:c6079300-6078989 [Pseudomonas corrugata]
ATGGCTAAGAAATTTGCCGATCTGGTGGCACGTCGTTCGCCAGATTCTCAGGTCCGCACGCAAGCGCTGTATCAGAAGTT
ACGGGCGGAAATGCCACTGCACGAGTTACGTCAGGCGCAGGAACTGAGCCAGGAAGCCTTGGCCAAGGCGCTGCATATCA
ACCAGGCGGCAGTCTCGAAAATGGAGCGTCGCACGGACATGTACATCAGCACGTTGCGTAACTACATCCGTGCCATGGGC
GGCGAATTGGAGATTATCGCCACGTTTCCGGATGGTCAGGTCAGGATCGAAAACTTCTCCCATCAACCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References