Detailed information of TA system TA206167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 75618..76150
• Replicon: chromosome
• Accession: NZ_CP076660
• Organism: Staphylococcus aureus strain SG511 Berlin

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: KQU62_RS00405
• Protein ID: WP_123090134.1
• Coordinates: 75830..76150 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IA75
• Locus tag: KQU62_RS00400
• Protein ID: WP_001058492.1
• Coordinates: 75618..75827 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQU62_RS00360 (70722)	70722..71225	+	504	WP_000934799.1	single-stranded DNA-binding protein	-
KQU62_RS00365 (71277)	71277..71519	+	243	WP_000897044.1	30S ribosomal protein S18	-
KQU62_RS00370 (71751)	71751..72584	-	834	WP_180372434.1	type II toxin-antitoxin system PemK/MazF family toxin	-
KQU62_RS00375 (72585)	72585..73799	-	1215	WP_123090135.1	site-specific integrase	-
KQU62_RS00380 (74098)	74098..74832	-	735	WP_000142630.1	helix-turn-helix transcriptional regulator	-
KQU62_RS00385 (74982)	74982..75194	+	213	WP_053040300.1	helix-turn-helix transcriptional regulator	-
KQU62_RS00390 (75195)	75195..75467	+	273	WP_053040301.1	helix-turn-helix domain-containing protein	-
KQU62_RS00395 (75479)	75479..75625	+	147	WP_000784885.1	hypothetical protein	-
KQU62_RS00400 (75618)	75618..75827	+	210	WP_001058492.1	hypothetical protein	Antitoxin
KQU62_RS00405 (75830)	75830..76150	+	321	WP_123090134.1	DUF1474 family protein	Toxin
KQU62_RS00410 (76214)	76214..77083	+	870	WP_053040303.1	primase alpha helix C-terminal domain-containing protein	-
KQU62_RS00415 (77100)	77100..78569	+	1470	WP_053040304.1	virulence-associated E family protein	-
KQU62_RS00420 (78848)	78848..79075	+	228	Protein_85	pathogenicity island protein	-
KQU62_RS00430 (80721)	80721..80873	+	153	Protein_87	pathogenicity island protein	-
KQU62_RS00435 (80866)	80866..81138	+	273	WP_000477476.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	66662..93628	26966

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12636.18 Da
• Isoelectric Point: 4.8637

>T206167 WP_123090134.1 NZ_CP076660:75830-76150 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEGRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T206167 NZ_CP102177:5877769-5878413 [Pseudomonas corrugata]
ATGATCTACAGCAGACTGAATCCTGAGAAGGCTCTGATTTGGCGTATCGTCCATCGCGACAACCTGCCTTGGATTCTGGA
CAATGGTCTGCACTGTGCAAACTCAACTGTTCGGTCGTCACAGTACGTAAACATCGGCAACGCTGACTTGATCGACAAGC
GCCGCACCCGGCATGTACCCATAGCTCCGGGAGGGGTACTGTCCGACTACGTGCCCTTCTATTTCACCCCCTTCTCTGTG
ATGATGAAGAACATCCATTCCGGGCGGAGTGTTCAGCAGCGGAGCAACGACGAGATCTTGATTCTGGTCTCCAGTCTGTA
CCTCGTTGAGCAGATGGGCTTTCCGTTTGTCTACACGAATGCGCATGCCTACCCGGATTGGACAGACTATTACAGCGATC
TGGCGAATCTCGATCAGATCGATTGGTCTATCATTCAACGACGCGATTTCAAGCGTGAACCTGACGACCCTCGGAAGATG
GAGCGGTATCAGGCCGAAGCGCTGATCCACAATCACCTACCGATTACAGGACTCCTTGGCATCATGTGCTACACCGATGC
AATGAAAAAACGTATAGATCGGGACGTGGCCGCTAGGGGCCTGACGTTGTCTGTTCATGCGCGTCCGGGATGGTATTTCC
AATGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT206167 WP_001058492.1 NZ_CP076660:75618-75827 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT206167 NZ_CP102177:5878410-5879498 [Pseudomonas corrugata]
ATGATCCGATTCACCCAAGGCAACCTTCTGGAAGCCAAAACCGAAGCCCTGGTCAACACGGTGAATACCGTGGGCGTGAT
GGGTAAAGGTATCGCGCTCATGTTCAAGGAGCGCTTCGCGGAGAACTACCGGCTGTACTCGGCCGCCTGCAAGGCTCGCG
AAGTGGAAACAGGTAAGGTTCACGTGACAGCGGTTAACGAGCTGGAAGGTCCTCGTTGGATCGTGAACTTCCCCACCAAA
CGGCACTGGCGATCACCGTCGCAGATGGCATGGATCACCGAAGGTTTACACGATCTGCGTCGTTTCCTGATTGAAAACGA
TGTGAAGTCCGTCGCGGTTCCACCGCTAGGTGCGGGCAACGGTGGTTTGAAGTGGCCAGAGGTTCGCGAACAGATTGTTG
AGATCTTGAGTGATCTAGATGTCGATGTACTGGTGTTCGAACCTTCTAACCAGTATCTGAACATCTCTAAGCGTAGCGGT
GTGGAAAAGCTCACGCCGGCTCGTGCGCTGATCGCTGAACTGGTTCGTCGCTACTGGGTTCTGGGTATGGAATGCAGCCT
GCTTGAGATTCAGAAGCTGGCTTGGTTTCTTGAGCGGGCGATTGAACAGTTACCGAATACCGAAAACCCTCTGAACCTTC
GGTTCGTGGCTCATAAGTACGGGCCGTATGCCAACCGGTTGGAGCATCTGCTCAATAACCTGGACGGCAGCTACTTGCAT
TGCGACAAGCGCATCAGTGATGCAGGTATCAGTGATGTGATCTGGTTTGACGAAGGGCGTAAGGCATTCTTGCAGGCCTA
CCTTCAAACAGAAGCGAAGGAATACACCCGGGCCTTGGAGCGCACCGCCGAGTTAATCGATGGTTTTGAGTCGCCTTTCG
GCATGGAGTTGTTGGCGACGGTTGATTGGTTGCTGAGCCAGGATGGGATTTCGCCGACTGTTCCTGCCGTGCGCGAGGCA
TTGAAGCATTGGGATGGCGGAGCGGGTGCTGCGGCTCGCAAAAGCAAGCTGTTCGATGATCAGGCGCTTGATATCGCGCT
GAAACGGCTGACTTCTAGTAGTTTCAGGCCGGAGGTTGCGACCTGTTAG

Structures

Antitoxin

• AlphaFold DB: X5IA75