Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 750915..751489 Replicon chromosome
Accession NZ_CP076656
Organism Pasteurella sp. XG20

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KPF51_RS03390 Protein ID WP_061406134.1
Coordinates 750915..751199 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag KPF51_RS03395 Protein ID WP_061406133.1
Coordinates 751196..751489 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPF51_RS03370 (KPF51_03370) 746708..748297 - 1590 WP_081106270.1 AAA family ATPase -
KPF51_RS03375 (KPF51_03375) 748582..749073 - 492 WP_256447825.1 NERD domain-containing protein -
KPF51_RS03380 (KPF51_03380) 749301..749636 + 336 WP_223848039.1 DUF3418 domain-containing protein -
KPF51_RS03390 (KPF51_03390) 750915..751199 + 285 WP_061406134.1 hypothetical protein Toxin
KPF51_RS03395 (KPF51_03395) 751196..751489 + 294 WP_061406133.1 putative addiction module antidote protein Antitoxin
KPF51_RS03400 (KPF51_03400) 751892..752569 - 678 WP_005726756.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
KPF51_RS03405 (KPF51_03405) 752587..753054 - 468 WP_064661066.1 PTS sugar transporter subunit IIA -
KPF51_RS03410 (KPF51_03410) 753099..754889 - 1791 WP_061406132.1 PTS ascorbate-specific subunit IIBC -
KPF51_RS03415 (KPF51_03415) 755240..756331 + 1092 WP_005751571.1 L-ascorbate 6-phosphate lactonase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-87)

Antitoxin

Uncharacterized protein HI1420

(7-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10667.40 Da        Isoelectric Point: 10.2297

>T206165 WP_061406134.1 NZ_CP076656:750915-751199 [Pasteurella sp. XG20]
VGRLKEVKILSAKSAVLARINKAMNGNFGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

>T206165 NZ_CP102177:c378576-378160 [Pseudomonas corrugata]
ATGATCAAATTCATGCTGGATACCAACATCTGTATTTTCACCATCAAGAACAAACCCCAGATGGTCAGAGAAGCTCTCAA
TCTGCATCACGGCCAGCTTTGCATTAGTGCCGTTACGCTGATGGAGCTGATCTACGGCGCAGAAAAGTCTTGCGCCCCAG
AAAGAAATCTCGCCGTCATCGAAGGCTTCTGTGCTCGCCTTGAGGTTCTACCATTTGGTTATGAAGCTGCCGCACATACC
GGAATGATTCGAGCCGAACTGGCGAAGGCAGGCAAGCCAATCGGCCCTTACGACCAAATGATTGCCGGCCATGCCCGTTC
TCTCGGGCTGATCGTGATAACCAACAATCTGAAGGAGTTTGAAAGAGTTCCGGGACTGCGCACCGAAGATTGGACCGTTG
CGAAAGGGCCAGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10947.88 Da        Isoelectric Point: 8.9149

>AT206165 WP_061406133.1 NZ_CP076656:751196-751489 [Pasteurella sp. XG20]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALSDVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKIMHSLGIKLVPTHI

Download         Length: 294 bp

>AT206165 NZ_CP102177:c378807-378577 [Pseudomonas corrugata]
ATGGAACAAACCACCCTTTTCATGAGCAACCGCAGCCAAGCGGTCCGGCTTCCCAAAGCAGTGGCGATGCCAAGCGACGT
GAAGCGTGTAGATGTAATCGCCGTCGGCAGAGCCCGAATCATTACCCCGGCCGGAGAAGCATGGGACAGCTGGTTCGATG
GAGATACCGTGACAGCTGACTTTATGACAGACCGCGATCAGCCCGCCGATCAGGAGCGTGAACCCTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References