Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 72133..72668 | Replicon | plasmid unnamed |
| Accession | NZ_CP076655 | ||
| Organism | Escherichia coli strain NC19 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | V0VJJ7 |
| Locus tag | KPE96_RS23570 | Protein ID | WP_000222760.1 |
| Coordinates | 72381..72668 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V0VIP2 |
| Locus tag | KPE96_RS23565 | Protein ID | WP_001132900.1 |
| Coordinates | 72133..72384 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KPE96_RS23525 (67260) | 67260..67820 | + | 561 | WP_000139315.1 | fertility inhibition protein FinO | - |
| KPE96_RS23530 (67956) | 67956..68168 | + | 213 | WP_001299730.1 | ANR family transcriptional regulator | - |
| KPE96_RS23535 (68414) | 68414..68488 | + | 75 | Protein_70 | endonuclease | - |
| - (68744) | 68744..68805 | - | 62 | NuclAT_1 | - | - |
| - (68744) | 68744..68805 | - | 62 | NuclAT_1 | - | - |
| - (68744) | 68744..68805 | - | 62 | NuclAT_1 | - | - |
| - (68744) | 68744..68805 | - | 62 | NuclAT_1 | - | - |
| KPE96_RS23540 (68849) | 68849..68998 | + | 150 | WP_001312851.1 | Hok/Gef family protein | - |
| KPE96_RS23545 (69282) | 69282..69539 | + | 258 | WP_000083845.1 | replication regulatory protein RepA | - |
| KPE96_RS24235 (69556) | 69556..69807 | - | 252 | WP_223195197.1 | replication protein RepA | - |
| KPE96_RS24240 (69798) | 69798..69845 | + | 48 | WP_229471593.1 | hypothetical protein | - |
| KPE96_RS23555 (69838) | 69838..70320 | + | 483 | WP_001273588.1 | hypothetical protein | - |
| KPE96_RS23560 (70313) | 70313..71170 | + | 858 | WP_000774297.1 | incFII family plasmid replication initiator RepA | - |
| KPE96_RS23565 (72133) | 72133..72384 | + | 252 | WP_001132900.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KPE96_RS23570 (72381) | 72381..72668 | + | 288 | WP_000222760.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KPE96_RS24245 (72772) | 72772..73092 | + | 321 | Protein_79 | serine acetyltransferase | - |
| KPE96_RS23575 (73108) | 73108..73455 | - | 348 | Protein_80 | IS1-like element IS1A family transposase | - |
| KPE96_RS23580 (73544) | 73544..74566 | + | 1023 | WP_000255956.1 | IS21-like element IS100 family transposase | - |
| KPE96_RS23585 (74563) | 74563..75345 | + | 783 | WP_001442137.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
| KPE96_RS23590 (75400) | 75400..75764 | - | 365 | Protein_83 | IS1 family transposase | - |
| KPE96_RS23595 (75864) | 75864..77085 | + | 1222 | Protein_84 | ISL3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | sitABCD | iutA / iucD / iucC / iucB / iucA / vat / iroN / iroE / iroD / iroC / iroB | 1..166302 | 166302 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11105.15 Da Isoelectric Point: 10.5832
>T206164 WP_000222760.1 NZ_CP076655:72381-72668 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
Download Length: 288 bp
>T206164 NZ_CP102176:5378158-5378451 [Pseudomonas mediterranea]
ATGACCTATAGCCTCGAGTTTGATCGACGTGCATTAAAAGAATGGAACAAGCTAGGCGATACACTGCGACAACAGTTCAA
AAAGAAACTGATCGAGGTACTTGAAAACCCTCGCATCGAAGCCAATCGACTTAGACAACTTCCCGACTGCTACAAGTTGA
AATTGCGAAGCGCCGGGTATCGCCTGATCTACCAAGTTATTGATCAGGAAGTTGTGGTGTTCGTTGTTGCGATAGGAAAA
CGCGAGCGTGAAGCAGTTTATCAAGATGTGCAGGAGCGCATCTCATCCGATTGA
ATGACCTATAGCCTCGAGTTTGATCGACGTGCATTAAAAGAATGGAACAAGCTAGGCGATACACTGCGACAACAGTTCAA
AAAGAAACTGATCGAGGTACTTGAAAACCCTCGCATCGAAGCCAATCGACTTAGACAACTTCCCGACTGCTACAAGTTGA
AATTGCGAAGCGCCGGGTATCGCCTGATCTACCAAGTTATTGATCAGGAAGTTGTGGTGTTCGTTGTTGCGATAGGAAAA
CGCGAGCGTGAAGCAGTTTATCAAGATGTGCAGGAGCGCATCTCATCCGATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9211.41 Da Isoelectric Point: 4.0780
>AT206164 WP_001132900.1 NZ_CP076655:72133-72384 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
Download Length: 252 bp
>AT206164 NZ_CP102176:5377929-5378168 [Pseudomonas mediterranea]
ATGGCTTCTATCAACATTCGCATCGACGACGACCTGAAGCAGCGATCATTCGCCGAGCTGGAGAAGCTCGGCGTCACACC
TTCCGAGTTGCTGCGTCAGACACTTCAGTACGTAGCAGAGCGAGGCAAGCTGCCTTTTAAAGCAGCTCTGCTCAGTGAAG
AAGACGAAGCACTCATTGCGGTGGTAACGGAGCGTCTTTCCAACCCTCAACGAGTGAAGGTCAGCCTGGATGACCTATAG
ATGGCTTCTATCAACATTCGCATCGACGACGACCTGAAGCAGCGATCATTCGCCGAGCTGGAGAAGCTCGGCGTCACACC
TTCCGAGTTGCTGCGTCAGACACTTCAGTACGTAGCAGAGCGAGGCAAGCTGCCTTTTAAAGCAGCTCTGCTCAGTGAAG
AAGACGAAGCACTCATTGCGGTGGTAACGGAGCGTCTTTCCAACCCTCAACGAGTGAAGGTCAGCCTGGATGACCTATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|