Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1393649..1394274 Replicon chromosome
Accession NZ_CP076654
Organism Escherichia coli strain NC19

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KPE96_RS06820 Protein ID WP_000911330.1
Coordinates 1393876..1394274 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag KPE96_RS06815 Protein ID WP_000450524.1
Coordinates 1393649..1393876 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPE96_RS06790 (1389452) 1389452..1389922 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
KPE96_RS06795 (1389922) 1389922..1390494 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
KPE96_RS06800 (1390640) 1390640..1391518 + 879 WP_216696493.1 4-hydroxy-tetrahydrodipicolinate synthase -
KPE96_RS06805 (1391535) 1391535..1392569 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
KPE96_RS06810 (1392782) 1392782..1393495 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
KPE96_RS06815 (1393649) 1393649..1393876 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
KPE96_RS06820 (1393876) 1393876..1394274 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
KPE96_RS06825 (1394421) 1394421..1395284 + 864 WP_001267507.1 neutral zinc metallopeptidase -
KPE96_RS06830 (1395299) 1395299..1397314 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
KPE96_RS06835 (1397388) 1397388..1398086 + 699 WP_000679823.1 esterase -
KPE96_RS06840 (1398196) 1398196..1398396 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T206144 WP_000911330.1 NZ_CP076654:1393876-1394274 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T206144 NZ_CP102152:c1967676-1967347 [Streptococcus suis]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT206144 WP_000450524.1 NZ_CP076654:1393649-1393876 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT206144 NZ_CP102152:c1967953-1967666 [Streptococcus suis]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References