Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 809141..809939 | Replicon | chromosome |
| Accession | NZ_CP076654 | ||
| Organism | Escherichia coli strain NC19 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | U9XMP3 |
| Locus tag | KPE96_RS03970 | Protein ID | WP_000854735.1 |
| Coordinates | 809141..809518 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1M1EW42 |
| Locus tag | KPE96_RS03975 | Protein ID | WP_032153712.1 |
| Coordinates | 809565..809939 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KPE96_RS03935 (804455) | 804455..805327 | + | 873 | WP_173672906.1 | DNA-binding domain-containing protein | - |
| KPE96_RS03940 (805385) | 805385..806377 | + | 993 | WP_029403189.1 | site-specific integrase | - |
| KPE96_RS03945 (806835) | 806835..807161 | - | 327 | WP_000779483.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KPE96_RS03950 (807158) | 807158..807421 | - | 264 | WP_025492088.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| KPE96_RS03955 (807493) | 807493..808359 | - | 867 | WP_032153714.1 | DUF4942 domain-containing protein | - |
| KPE96_RS03960 (808444) | 808444..808641 | - | 198 | WP_000839265.1 | DUF957 domain-containing protein | - |
| KPE96_RS03965 (808653) | 808653..809144 | - | 492 | WP_023155722.1 | DUF5983 family protein | - |
| KPE96_RS03970 (809141) | 809141..809518 | - | 378 | WP_000854735.1 | TA system toxin CbtA family protein | Toxin |
| KPE96_RS03975 (809565) | 809565..809939 | - | 375 | WP_032153712.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| KPE96_RS03980 (810019) | 810019..810240 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| KPE96_RS03985 (810309) | 810309..810785 | - | 477 | WP_001186715.1 | RadC family protein | - |
| KPE96_RS03990 (810801) | 810801..811285 | - | 485 | Protein_783 | antirestriction protein | - |
| KPE96_RS03995 (811377) | 811377..812195 | - | 819 | WP_001234693.1 | DUF932 domain-containing protein | - |
| KPE96_RS04000 (812286) | 812286..812495 | - | 210 | WP_023155727.1 | DUF905 family protein | - |
| KPE96_RS04005 (812525) | 812525..813202 | - | 678 | WP_023155728.1 | hypothetical protein | - |
| KPE96_RS04010 (813321) | 813321..814205 | - | 885 | WP_024166630.1 | 50S ribosome-binding GTPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR | papI / papB | 785952..874314 | 88362 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14061.07 Da Isoelectric Point: 8.2904
>T206140 WP_000854735.1 NZ_CP076654:c809518-809141 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T206140 NZ_CP102152:605679-605939 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13697.51 Da Isoelectric Point: 6.6240
>AT206140 WP_032153712.1 NZ_CP076654:c809939-809565 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT206140 NZ_CP102152:605456-605677 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U9XMP3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M1EW42 |