Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 261549..262135 Replicon chromosome
Accession NZ_CP076654
Organism Escherichia coli strain NC19

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag KPE96_RS01185 Protein ID WP_042014162.1
Coordinates 261549..261779 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag KPE96_RS01190 Protein ID WP_000593555.1
Coordinates 261776..262135 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPE96_RS01175 (257586) 257586..260321 + 2736 WP_048943289.1 ribosome-associated ATPase/putative transporter RbbA -
KPE96_RS01180 (260321) 260321..261445 + 1125 WP_001314210.1 ABC transporter permease -
KPE96_RS01185 (261549) 261549..261779 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
KPE96_RS01190 (261776) 261776..262135 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KPE96_RS01195 (262255) 262255..262656 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
KPE96_RS01200 (262662) 262662..263468 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
KPE96_RS01205 (263465) 263465..264229 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
KPE96_RS01210 (264229) 264229..265062 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
KPE96_RS01215 (265059) 265059..266003 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T206136 WP_042014162.1 NZ_CP076654:261549-261779 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T206136 NZ_CP102149:1344432-1344689 [Streptococcus suis]
ATGGGAATCCATTTCACAGACGACGCCTGGGAAGACTATCCTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGCGAAT
CAATAAGATTATCAAGGATATGCAACGACATCCTTTTGAAGGCATTGCCAAGCCAGAACCTTTGAAGTATGATTATCAGG
GAGCCTGGTCAAGAAGGATTGATGCGGAGAATCGCTTGATTTATATGGTAGAAGCTGACCAGTTGTATATCTTGTCGCTA
AAGGACCGTTATAAGTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT206136 WP_000593555.1 NZ_CP076654:261776-262135 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT206136 NZ_CP102149:1344170-1344430 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAGCCCTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGCGAGTGGGATAGCTTACAAGAAACCCTCG
CTGTTGCTCGGAACGCCTACCTATCTCAGAAAGTCTTGCGTGGTATGGCTCAAGTCAAAGCGGGGCAAACCCAAGAACGC
AATCTGATAGAGGTGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References