Detailed information of TA system TA206135

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 5037767..5038745
• Replicon: chromosome
• Accession: NZ_CP076653
• Organism: Bacillus sp. NP247

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: KPL75_RS26145
• Protein ID: WP_219918440.1
• Coordinates: 5037767..5038507 (+)
• Length: 247 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: R8HWP4
• Locus tag: KPL75_RS26150
• Protein ID: WP_000588712.1
• Coordinates: 5038620..5038745 (+)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPL75_RS26120 (KPL75_26110)	5033402..5033809	+	408	WP_002147959.1	VOC family protein	-
KPL75_RS26125 (KPL75_26115)	5034143..5034925	+	783	WP_219918432.1	class I SAM-dependent methyltransferase	-
KPL75_RS26130 (KPL75_26120)	5035099..5035975	-	877	Protein_5106	thiamine pyrophosphate-dependent enzyme	-
KPL75_RS26135 (KPL75_26125)	5036083..5036565	+	483	WP_219918435.1	MarR family winged helix-turn-helix transcriptional regulator	-
KPL75_RS26140 (KPL75_26130)	5036733..5037470	+	738	WP_219918437.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
KPL75_RS26145 (KPL75_26135)	5037767..5038507	+	741	WP_219918440.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
KPL75_RS26150 (KPL75_26140)	5038620..5038745	+	126	WP_000588712.1	hypothetical protein	Antitoxin
KPL75_RS26155 (KPL75_26145)	5038821..5038997	+	177	WP_000852629.1	stage II sporulation protein SB	-
KPL75_RS26160 (KPL75_26150)	5039017..5039406	-	390	WP_219918442.1	YxeA family protein	-
KPL75_RS26165 (KPL75_26155)	5039618..5041087	+	1470	WP_219918444.1	beta-Ala-His dipeptidase	-
KPL75_RS26170 (KPL75_26160)	5041110..5041268	-	159	WP_258237061.1	hypothetical protein	-
KPL75_RS26175 (KPL75_26165)	5041673..5042149	-	477	WP_219918451.1	DUF5065 family protein	-
KPL75_RS26180 (KPL75_26170)	5042602..5043261	+	660	WP_219918454.1	CatB-related O-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-244)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 247 a.a.
• Molecular weight: 28384.03 Da
• Isoelectric Point: 8.2998

>T206135 WP_219918440.1 NZ_CP076653:5037767-5038507 [Bacillus sp. NP247]
MTISNIRIGLFILVIAFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAAFGTMEWHTEEEYTKSLNAFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSSIVPLEHIEQLNEQKAVQVENVGIIPAKTVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Nucleotide

• Length: 741 bp

>T206135 NZ_CP102149:1292616-1293392 [Streptococcus suis]
ATGAGATTGGAAGAATTTAGTGAGGCTGACTTTCAGAAGGCTTTACAGCGAACCATTCGGGCTTTAACCCGAGGAAAGAC
GATCCCAGATCGACCGAAAGCTATCTTGCTTGGAGGACAAAGCGGGGCTGGTAAGACGACTATTCATCGTATCAAGCAAA
AGGAATTTCAAGGTAATATCATTATCATTGATGGTGATAGCTGCCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
GAGTATGGGAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACAGTTGGTTGATGAACTCAGCAC
GCAAGGCTATCATTTGCTGATTGAGGGAACTTTGCGAACTACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCATCAA
AAGGCTACCAAGTTTCCTTAGCTATTATCGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCCATCGATCCCAATCAGGCCAGAGCAACACCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTGGATAA
CTTGAGGGAGTTAGAAAGTGAGAAACTCTTTGAACGAATTCAAATTTACCAAAGAGATAGAACTTGTATATATGATTCTG
AATCAGATGAAGGTTTCGTAGCAGAAGTGTTACAAGAGTGTCTCTTTGGAAAATGGAGTAAGGTAGAGGAAGAGATGATG
AAGTTTGGACAGGAACGGTTGAGGGAGATGAGTAAAAGTAATGGAAACGATGTATAG

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4938.34 Da
• Isoelectric Point: 3.9150

>AT206135 WP_000588712.1 NZ_CP076653:5038620-5038745 [Bacillus sp. NP247]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Nucleotide

• Length: 126 bp

>AT206135 NZ_CP102149:1292140-1292616 [Streptococcus suis]
ATGATCGGAGAAAATATAAAATCACTACGCCAGACACATGATTTAACACAACCAGAATTTGCGAAAATGGTGGGGATTTC
ACGCAATAGCCTGAGTCGCTATGAAAATGGCACCAGCACCGTATCAACAGAGCTTATCGACCGCATTTGTCAGAAATTTA
ACGTCTCTTATGTCGATATTGTAGGGGAGGATAAGATGCTAACACCTGTTGAAGATTACCAACTGACTTTAAAAATAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGAGATTGCTTTTGATGATGA
AGCGAATCCTTGGATTTTGATGAGTGATGACTTGGCTGAATTGATCAATACGAAAATTTACCTTGTCGATACCTTCGATG
AAATCGAGCGTTACAATGGTTATTTAGATGGTATTGAGCGGATGTTAGAGATGGTGCATCATCGGGTGGTGGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A366GQT1