Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4410512..4411134 Replicon chromosome
Accession NZ_CP076652
Organism Pseudomonas savastanoi strain MHT1

Toxin (Protein)


Gene name hicA Uniprot ID A0A658PBH1
Locus tag KP808_RS18610 Protein ID WP_003434313.1
Coordinates 4410952..4411134 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A193SSY5
Locus tag KP808_RS18605 Protein ID WP_024661723.1
Coordinates 4410512..4410916 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP808_RS18590 (KP808_18555) 4406278..4406946 + 669 WP_230016643.1 ABC transporter ATP-binding protein -
KP808_RS18595 (KP808_18560) 4406946..4409426 + 2481 WP_230016644.1 ABC transporter permease -
KP808_RS18600 (KP808_18565) 4409416..4410495 + 1080 WP_230016645.1 lipocalin-like domain-containing protein -
KP808_RS18605 (KP808_18570) 4410512..4410916 - 405 WP_024661723.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KP808_RS18610 (KP808_18575) 4410952..4411134 - 183 WP_003434313.1 type II toxin-antitoxin system HicA family toxin Toxin
KP808_RS18615 (KP808_18580) 4411418..4413190 + 1773 WP_230016646.1 N-acetylglutaminylglutamine amidotransferase -
KP808_RS18620 (KP808_18585) 4413194..4414942 + 1749 WP_054071106.1 N-acetylglutaminylglutamine synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6777.99 Da        Isoelectric Point: 10.6643

>T206132 WP_003434313.1 NZ_CP076652:c4411134-4410952 [Pseudomonas savastanoi]
VQSRQLIKELEADGWILDRVSGSHHMFKHPEKLQTVPVPHPKKDLPFGTVRAIKKLAGLV

Download         Length: 183 bp

>T206132 NZ_CP102148:c2013551-2013294 [Streptococcus suis]
ATGGGAATCCATTTTACAGAGGATGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTCAAGCGAAT
CAATAAGATTATCAAGGATATGCAACGACATCCTTTTGAAGGTATTGCTAAACCAGAACCTTTGAAGTATGATTATCAAG
GCGCCTGGTCGAGACGAATTGATGCGGAGAATCGCTTGATTTATATGGTAGAAGCAGATAAGCTGTATATTTTGTCTTTA
AAGGATCATTATGGGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14345.43 Da        Isoelectric Point: 5.1643

>AT206132 WP_024661723.1 NZ_CP076652:c4410916-4410512 [Pseudomonas savastanoi]
MKYPMCIEWGSETTAFGIQIPDIPGAVTAGDTFEEAHAAAVEIAHIMLQEIAAGGGTIPKAGTVAEHARNADFAGMGWGM
IEIDVTPYLGKTEKVNVTLPGFVIKQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp

>AT206132 NZ_CP102148:c2013813-2013553 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAACGACGAGTTTGAGCCTTT
AGTTGTGGTCAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTTTTGCGTGGTATGGCTCAAGTCAAAGCGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A658PBH1

Antitoxin

Source ID Structure
AlphaFold DB A0A193SSY5

References