Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3503964..3504489 Replicon chromosome
Accession NZ_CP076651
Organism Serratia ureilytica strain S24

Toxin (Protein)


Gene name relE Uniprot ID A0A8B4GJ35
Locus tag KQJ82_RS16590 Protein ID WP_033633469.1
Coordinates 3503964..3504248 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag KQJ82_RS16595 Protein ID WP_004928423.1
Coordinates 3504238..3504489 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQJ82_RS16565 (KQJ82_16565) 3499168..3500301 + 1134 WP_043137773.1 putrescine ABC transporter ATP-binding subunit PotG -
KQJ82_RS16570 (KQJ82_16570) 3500326..3501288 + 963 WP_042784087.1 putrescine ABC transporter permease PotH -
KQJ82_RS16575 (KQJ82_16575) 3501285..3502130 + 846 WP_033642528.1 putrescine ABC transporter permease PotI -
KQJ82_RS16580 (KQJ82_16580) 3502292..3502771 + 480 WP_047024958.1 YbjO family protein -
KQJ82_RS16585 (KQJ82_16585) 3502840..3503967 + 1128 WP_033642530.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
KQJ82_RS16590 (KQJ82_16590) 3503964..3504248 - 285 WP_033633469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQJ82_RS16595 (KQJ82_16595) 3504238..3504489 - 252 WP_004928423.1 prevent-host-death protein Antitoxin
KQJ82_RS16600 (KQJ82_16600) 3504591..3505325 - 735 WP_015377297.1 arginine ABC transporter substrate-binding protein -
KQJ82_RS16605 (KQJ82_16605) 3505525..3506193 - 669 WP_033650651.1 arginine ABC transporter permease ArtM -
KQJ82_RS16610 (KQJ82_16610) 3506193..3506909 - 717 WP_025159684.1 arginine ABC transporter permease ArtQ -
KQJ82_RS16615 (KQJ82_16615) 3506919..3507650 - 732 WP_033642533.1 arginine ABC transporter substrate-binding protein -
KQJ82_RS16620 (KQJ82_16620) 3507683..3508411 - 729 WP_089192582.1 arginine ABC transporter ATP-binding protein ArtP -
KQJ82_RS16625 (KQJ82_16625) 3508676..3509218 - 543 WP_033642535.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10789.91 Da        Isoelectric Point: 10.6941

>T206123 WP_033633469.1 NZ_CP076651:c3504248-3503964 [Serratia ureilytica]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

>T206123 NZ_CP102145:359736-360581 [Streptococcus suis]
ATGAATAAAGCTAAATTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGTTTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTTGAAGTCATTTTGAAAAAATTAAGTCAAAGTTCTTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TTTCGAATGTCATCGGAGTTGAATCTCGTAGCACTGTTGATATTGACTTTTTATTCCATCAAATAACACTCTCAGAAGAA
ACTGTTAAACAGCAACTTGAAGAAGTTTTAGCAGATTCTGATGAAGGTATATCTTTTGTGATTCAATCAATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACCATTTTGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATAACGTACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAGAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTAGTCTTATTACAATTATTATTTCTACTGACTCTGATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT206123 WP_004928423.1 NZ_CP076651:c3504489-3504238 [Serratia ureilytica]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT206123 NZ_CP102145:359149-359739 [Streptococcus suis]
ATGTCAAAAAAAGAGATTCTACTCGATTTTATAGAAAAGAACAATGGAATTGTCACAAACAAAGATTGTAAAGCACTAGG
TATTCCAACAATATATCTGACAAGACTAGAGAAAGAAGGCATTATCTTCCGAGTTGAAAAAGGTATTTTCCTAACCCAAA
ACGGAGACTACGACGAATACTACTTCTTTCAATATCGTTTTCCTAAGGCTATTTTCTCTTATATTTCGGCACTGTATCTA
CAACAGTTTACAGATGAAATTCCACAATATTTTGATGTGACAGTTCCTAGAGGCTACCGCTTTAATACTCCTCCAGCTAA
TCTAAATATTCACTTTGTCTCTAAAGAATACAGCGAGCTGGGAATGACTACTGTACCTACTCCTATGGGAAACAACGTAA
GGGTATATGATTTTGAACGTGTTATTTGTGACTTTGTAATACATCGAGAAAAGATTGATTCCGAACTCTTTGTCAAGACA
CTTCAATCTTATGGGAACTATCCTAAAAAAAATCTAGCAAAACTCTATGAATATGCGACAAAAATGAATACTTTAGAAAA
AGTTAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GJ35

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References