Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2862585..2863207 Replicon chromosome
Accession NZ_CP076651
Organism Serratia ureilytica strain S24

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag KQJ82_RS13440 Protein ID WP_004940313.1
Coordinates 2862585..2862788 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag KQJ82_RS13445 Protein ID WP_004940312.1
Coordinates 2862839..2863207 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQJ82_RS13415 (KQJ82_13415) 2858393..2858857 + 465 WP_196018713.1 type II secretion system protein GspM -
KQJ82_RS13420 (KQJ82_13420) 2858873..2859688 + 816 WP_196018714.1 A24 family peptidase -
KQJ82_RS13425 (KQJ82_13425) 2859685..2860047 - 363 WP_052752709.1 type II secretion system pilot lipoprotein GspS -
KQJ82_RS13430 (KQJ82_13430) 2860305..2861732 + 1428 WP_196018715.1 N-acetylglucosamine-binding protein GbpA -
KQJ82_RS13435 (KQJ82_13435) 2861785..2862303 + 519 WP_033651103.1 cytochrome b/b6 domain-containing protein -
KQJ82_RS13440 (KQJ82_13440) 2862585..2862788 - 204 WP_004940313.1 HHA domain-containing protein Toxin
KQJ82_RS13445 (KQJ82_13445) 2862839..2863207 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
KQJ82_RS13450 (KQJ82_13450) 2863367..2863720 - 354 WP_047572432.1 hypothetical protein -
KQJ82_RS13455 (KQJ82_13455) 2864127..2864840 + 714 WP_033642104.1 ABC transporter ATP-binding protein -
KQJ82_RS13460 (KQJ82_13460) 2864837..2865694 + 858 WP_033642105.1 metal ABC transporter permease -
KQJ82_RS13465 (KQJ82_13465) 2865720..2866598 + 879 WP_033642106.1 metal ABC transporter substrate-binding protein -
KQJ82_RS13470 (KQJ82_13470) 2866704..2866844 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
KQJ82_RS13475 (KQJ82_13475) 2866857..2867111 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T206122 WP_004940313.1 NZ_CP076651:c2862788-2862585 [Serratia ureilytica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T206122 NZ_CP102145:c327100-326834 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAATTGAAAAAGTTGGATAAGTTTACCCAAAAACA
GATTACCAACTACCTGTCCAGTCATGTGACCGACAACCCCAGACAATACGGAAAAGCCTTGACGGCCAATCGTTCGGGCC
AATGGCGGTACCGTATCGGCAATTACAGGGTCATCGTCAGCATTGAGGATGATAAATTGATCGTAACAGCCCTTGAAGTC
GGGCATCGAAAAGAAGTATATAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT206122 WP_004940312.1 NZ_CP076651:c2863207-2862839 [Serratia ureilytica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT206122 NZ_CP102145:c327335-327084 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGCTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGATGAATACGATGCCCGTGTGGCAGACATTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATGGAATTGAGCCGATTAGCTGGGAGGAGATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References