Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1796771..1797372 Replicon chromosome
Accession NZ_CP076651
Organism Serratia ureilytica strain S24

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag KQJ82_RS08365 Protein ID WP_025304766.1
Coordinates 1796771..1797151 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag KQJ82_RS08370 Protein ID WP_025304767.1
Coordinates 1797151..1797372 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQJ82_RS08340 (KQJ82_08340) 1792018..1793298 + 1281 WP_033645140.1 DUF3748 domain-containing protein -
KQJ82_RS08345 (KQJ82_08345) 1793329..1793676 - 348 WP_016929593.1 YceK/YidQ family lipoprotein -
KQJ82_RS08350 (KQJ82_08350) 1793986..1794399 + 414 WP_004933919.1 small heat shock chaperone IbpA -
KQJ82_RS08355 (KQJ82_08355) 1794506..1794934 + 429 WP_004933922.1 small heat shock chaperone IbpB -
KQJ82_RS08360 (KQJ82_08360) 1795102..1796760 + 1659 WP_033652317.1 putative transporter -
KQJ82_RS08365 (KQJ82_08365) 1796771..1797151 - 381 WP_025304766.1 type II toxin-antitoxin system VapC family toxin Toxin
KQJ82_RS08370 (KQJ82_08370) 1797151..1797372 - 222 WP_025304767.1 ribbon-helix-helix domain-containing protein Antitoxin
KQJ82_RS08375 (KQJ82_08375) 1797446..1798696 - 1251 WP_033645138.1 valine--pyruvate transaminase -
KQJ82_RS08380 (KQJ82_08380) 1799724..1800503 + 780 WP_033645137.1 2OG-Fe dioxygenase family protein -
KQJ82_RS08385 (KQJ82_08385) 1800583..1801722 + 1140 WP_122004624.1 PLP-dependent aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T206120 WP_025304766.1 NZ_CP076651:c1797151-1796771 [Serratia ureilytica]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T206120 NZ_CP102143:c1511029-1510847 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACTAAAGGTGGTAAGGGGTCTCA
CGTTAAACTTGAAAAAGTAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT206120 WP_025304767.1 NZ_CP076651:c1797372-1797151 [Serratia ureilytica]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp

>AT206120 NZ_CP102143:c1510807-1510355 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTACCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAGGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGTGATATTCCCACTCCTACCCCTATTAACGCTTTATCATTGGCTGATAATAACCCTTTC
CGTGATGATAAGGACATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GSJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GSF3

References