Detailed information of TA system TA206117

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 867243..867912
• Replicon: chromosome
• Accession: NZ_CP076651
• Organism: Serratia ureilytica strain S24

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KQJ82_RS04080
• Protein ID: WP_196018844.1
• Coordinates: 867243..867665 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: KQJ82_RS04085
• Protein ID: WP_019455657.1
• Coordinates: 867646..867912 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQJ82_RS04060 (KQJ82_04060)	863132..863650	+	519	WP_033635825.1	flavodoxin FldB	-
KQJ82_RS04065 (KQJ82_04065)	863688..865052	-	1365	WP_033652165.1	cell envelope integrity protein CreD	-
KQJ82_RS04070 (KQJ82_04070)	865133..866551	-	1419	WP_033644779.1	two-component system sensor histidine kinase CreC	-
KQJ82_RS04075 (KQJ82_04075)	866548..867243	-	696	WP_033644777.1	two-component system response regulator CreB	-
KQJ82_RS04080 (KQJ82_04080)	867243..867665	-	423	WP_196018844.1	protein YgfX	Toxin
KQJ82_RS04085 (KQJ82_04085)	867646..867912	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
KQJ82_RS04090 (KQJ82_04090)	868233..869225	+	993	WP_047573794.1	tRNA-modifying protein YgfZ	-
KQJ82_RS04095 (KQJ82_04095)	869264..869761	-	498	WP_033644774.1	DUF2165 domain-containing protein	-
KQJ82_RS04100 (KQJ82_04100)	869912..870586	-	675	WP_033644772.1	hemolysin III family protein	-
KQJ82_RS04105 (KQJ82_04105)	870770..871378	+	609	WP_047573791.1	HD domain-containing protein	-
KQJ82_RS04110 (KQJ82_04110)	871419..872345	-	927	WP_033644768.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16456.51 Da
• Isoelectric Point: 10.6021

>T206117 WP_196018844.1 NZ_CP076651:c867665-867243 [Serratia ureilytica]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWQLAKKPWMPGYGLLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEEA

Nucleotide

• Length: 423 bp

>T206117 NZ_CP102143:c1050675-1050418 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT206117 WP_019455657.1 NZ_CP076651:c867912-867646 [Serratia ureilytica]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT206117 NZ_CP102143:c1050904-1050665 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04