Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 7943..8465 Replicon plasmid pNDM33-4
Accession NZ_CP076649
Organism Escherichia coli strain GD33

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag KP013_RS24720 Protein ID WP_000220561.1
Coordinates 7943..8224 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag KP013_RS24725 Protein ID WP_000121743.1
Coordinates 8214..8465 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP013_RS24690 (3513) 3513..4129 + 617 Protein_5 ProQ/FINO family protein -
KP013_RS24695 (4422) 4422..5459 - 1038 WP_044502555.1 permease -
KP013_RS24700 (5564) 5564..5887 + 324 WP_001175594.1 metalloregulator ArsR/SmtB family transcription factor -
KP013_RS24705 (6086) 6086..6790 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
KP013_RS24710 (6844) 6844..7446 + 603 Protein_9 transposase -
KP013_RS24715 (7612) 7612..7704 + 93 Protein_10 IS6 family transposase -
KP013_RS24720 (7943) 7943..8224 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KP013_RS24725 (8214) 8214..8465 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
KP013_RS24730 (9700) 9700..10539 + 840 WP_024129959.1 replication initiation protein -
KP013_RS24735 (10560) 10560..11402 + 843 WP_000435064.1 replication initiation protein -
KP013_RS24740 (11406) 11406..11852 + 447 WP_001074384.1 hypothetical protein -
KP013_RS24745 (11989) 11989..12342 + 354 WP_024129958.1 DNA distortion polypeptide 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid dfrA14 / ant(3'')-Ia / blaOXA-10 / cmlA1 / ARR-3 / tet(A) / floR / aph(6)-Id / aph(3'')-Ib / sul2 / fosA3 - 1..79203 79203


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T206113 WP_000220561.1 NZ_CP076649:c8224-7943 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T206113 NZ_CP102141:c2069444-2068677 [Streptococcus suis]
ATGAGGTTGGAAGAATTTAGTGAAGCTGAGTTTCAGAAGGCTTTACAGCGAACCATTCGGGCTTTAACCCGAGGAAAGAC
GATTCCAGATCAACCAAAAGCTATCTTGCTTGGAGGACAAAGCGGGGCAGGTAAGACGACTATTCATCGTATCAATCAAA
AAGAATTTCAAGGTAATATCATTGTCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATAGTAGAGCATCTGGTTGATGAACTTAGCAC
ACAAGGTTATCATTTGCTGATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGGTTACCAAGTTTCCTTAGCAGTGATTGGCACCAAACCAGAATTGTCATATCTCAGCACCTTAATTCGTTACGAGGAA
CTTTATGCCATAGATCCGACTCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTAGTTGATAA
CCTAAGGGAGTTAGAAAGTGAGAAACTCTTTGACCAGATTCAAATTTATCAAAGAGATAAAACTTGTGTCTATGATTCTG
AAACAGATGAAGGTTCAGCAGCAGAAGTTCTTCAAAATTGCCTTTTCGGAGAGTGGAGTAAAGTAGAGGAGGAGATGATG
AAGGTGGGAGAACTCCTACTTAATGAATTGCTTGAGAAAAATAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT206113 WP_000121743.1 NZ_CP076649:c8465-8214 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT206113 NZ_CP102141:c2069920-2069444 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCCTGAGCCGTTATGAAAATGGAACTAGTAAAGTTTCAACAGAACTAATTGACCGTATTTGTCAAAAATTTA
ACGTCTCTTATGTCGATATTGTAGGGGAAGACAAGATGTTAGCACCTGTTGAAGATTACCAACTGACTTTAAAAATAGAA
GTGATAAAAGAACGTGGAGCAGCAATATTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
ATCGAATCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCCATACGAAAATTTACCTTGTCGATACTTTCGATG
AGATTGAGCGTTACAATGGTTATTTAGACGGTATTGAGCGGATGTTAGAGATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References