Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3546002..3546620 Replicon chromosome
Accession NZ_CP076646
Organism Escherichia coli strain GD33

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KP013_RS17230 Protein ID WP_001291435.1
Coordinates 3546402..3546620 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KP013_RS17225 Protein ID WP_000344800.1
Coordinates 3546002..3546376 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP013_RS17215 (3541091) 3541091..3542284 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KP013_RS17220 (3542307) 3542307..3545456 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
KP013_RS17225 (3546002) 3546002..3546376 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KP013_RS17230 (3546402) 3546402..3546620 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KP013_RS17235 (3546792) 3546792..3547343 + 552 WP_000102564.1 maltose O-acetyltransferase -
KP013_RS17240 (3547459) 3547459..3547929 + 471 WP_000136192.1 YlaC family protein -
KP013_RS17245 (3548093) 3548093..3549643 + 1551 WP_063501968.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KP013_RS17250 (3549685) 3549685..3550038 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KP013_RS17260 (3550417) 3550417..3550728 + 312 WP_000409911.1 MGMT family protein -
KP013_RS17265 (3550759) 3550759..3551331 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T206104 WP_001291435.1 NZ_CP076646:3546402-3546620 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T206104 NZ_CP102140:c1007904-1007647 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT206104 WP_000344800.1 NZ_CP076646:3546002-3546376 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT206104 NZ_CP102140:c1008133-1007894 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References