Detailed information of TA system TA206103

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3045782..3046622
• Replicon: chromosome
• Accession: NZ_CP076646
• Organism: Escherichia coli strain GD33

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: KP013_RS14795
• Protein ID: WP_000854686.1
• Coordinates: 3045782..3046165 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A1M0YJ34
• Locus tag: KP013_RS14800
• Protein ID: WP_001360163.1
• Coordinates: 3046242..3046622 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP013_RS14765 (3042459)	3042459..3043163	+	705	WP_001241677.1	leucyl/phenylalanyl-tRNA--protein transferase	-
KP013_RS14770 (3043448)	3043448..3043666	+	219	WP_001040187.1	translation initiation factor IF-1	-
KP013_RS14780 (3044156)	3044156..3044998	-	843	WP_001274547.1	DUF4942 domain-containing protein	-
KP013_RS14785 (3045083)	3045083..3045280	-	198	WP_000839253.1	DUF957 domain-containing protein	-
KP013_RS14790 (3045297)	3045297..3045785	-	489	WP_001054233.1	DUF5983 family protein	-
KP013_RS14795 (3045782)	3045782..3046165	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
KP013_RS14800 (3046242)	3046242..3046622	-	381	WP_001360163.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KP013_RS14805 (3046633)	3046633..3047316	-	684	WP_000086769.1	hypothetical protein	-
KP013_RS14810 (3047335)	3047335..3047556	-	222	WP_000692298.1	DUF987 domain-containing protein	-
KP013_RS14815 (3047619)	3047619..3048095	-	477	WP_001186726.1	RadC family protein	-
KP013_RS14820 (3048111)	3048111..3048596	-	486	WP_000214307.1	antirestriction protein	-
KP013_RS14825 (3048688)	3048688..3049506	-	819	WP_001234732.1	DUF932 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T206103 WP_000854686.1 NZ_CP076646:c3046165-3045782 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T206103 NZ_CP102140:509263-509532 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13950.74 Da
• Isoelectric Point: 5.0823

>AT206103 WP_001360163.1 NZ_CP076646:c3046622-3046242 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCIVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT206103 NZ_CP102140:509046-509273 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1M0YJ34