Detailed information of TA system TA206102

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2473557..2474195
• Replicon: chromosome
• Accession: NZ_CP076646
• Organism: Escherichia coli strain GD33

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S1F9G9
• Locus tag: KP013_RS11925
• Protein ID: WP_000813794.1
• Coordinates: 2474019..2474195 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KP013_RS11920
• Protein ID: WP_001270286.1
• Coordinates: 2473557..2473973 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP013_RS11900 (2468707)	2468707..2469648	-	942	WP_001251313.1	ABC transporter permease	-
KP013_RS11905 (2469649)	2469649..2470662	-	1014	WP_000220399.1	ABC transporter ATP-binding protein	-
KP013_RS11910 (2470680)	2470680..2471827	-	1148	Protein_2336	ABC transporter substrate-binding protein	-
KP013_RS11915 (2472072)	2472072..2473478	-	1407	WP_000760585.1	PLP-dependent aminotransferase family protein	-
KP013_RS11920 (2473557)	2473557..2473973	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
KP013_RS11925 (2474019)	2474019..2474195	-	177	WP_000813794.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
KP013_RS11930 (2474417)	2474417..2474647	+	231	WP_000494244.1	YncJ family protein	-
KP013_RS11935 (2474739)	2474739..2476700	-	1962	WP_001301045.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
KP013_RS11940 (2476773)	2476773..2477309	-	537	WP_000429133.1	DNA-binding transcriptional regulator SutR	-
KP013_RS11945 (2477401)	2477401..2478576	+	1176	WP_001236251.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2478616..2479881	1265

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6749.83 Da
• Isoelectric Point: 11.2298

>T206102 WP_000813794.1 NZ_CP076646:c2474195-2474019 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T206102 NZ_CP102138:c1955049-1954792 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT206102 WP_001270286.1 NZ_CP076646:c2473973-2473557 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT206102 NZ_CP102138:c1955311-1955051 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Structures

Toxin

• PDB: 6HPB