Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1837310..1838141 Replicon chromosome
Accession NZ_CP076646
Organism Escherichia coli strain GD33

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag KP013_RS08770 Protein ID WP_000854814.1
Coordinates 1837310..1837684 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag KP013_RS08775 Protein ID WP_001285585.1
Coordinates 1837773..1838141 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP013_RS08730 (1832706) 1832706..1833872 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
KP013_RS08735 (1833991) 1833991..1834464 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
KP013_RS08740 (1834662) 1834662..1835720 + 1059 WP_001200891.1 FUSC family protein -
KP013_RS08745 (1835892) 1835892..1836221 + 330 WP_000450409.1 DUF496 family protein -
KP013_RS25645 (1836322) 1836322..1836645 - 324 WP_225343796.1 EutP/PduV family microcompartment system protein -
KP013_RS25650 (1836624) 1836624..1836704 + 81 WP_023441679.1 hypothetical protein -
KP013_RS08760 (1836993) 1836993..1837073 - 81 Protein_1714 hypothetical protein -
KP013_RS08765 (1837119) 1837119..1837313 - 195 WP_000988600.1 DUF5983 family protein -
KP013_RS08770 (1837310) 1837310..1837684 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KP013_RS08775 (1837773) 1837773..1838141 - 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
KP013_RS08780 (1838215) 1838215..1838436 - 222 WP_000692323.1 DUF987 domain-containing protein -
KP013_RS08785 (1838499) 1838499..1838975 - 477 WP_001186773.1 RadC family protein -
KP013_RS08790 (1838991) 1838991..1839470 - 480 WP_000860076.1 antirestriction protein -
KP013_RS08795 (1839552) 1839552..1840373 - 822 WP_001234530.1 DUF932 domain-containing protein -
KP013_RS08800 (1840594) 1840594..1841004 - 411 WP_000846713.1 hypothetical protein -
KP013_RS08805 (1841020) 1841020..1841703 - 684 WP_000775500.1 hypothetical protein -
KP013_RS08810 (1841839) 1841839..1842909 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T206093 WP_000854814.1 NZ_CP076646:c1837684-1837310 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T206093 NZ_CP102137:640561-641328 [Streptococcus suis]
ATGAGACTGGAAGAATTTAGTGAGGCTGAGTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGATCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AGGAATTTCAAGGTAATATCATTATTATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGATAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACAGTTGGTTGATGAACTCAGTAC
GCAAGGCTACCATTTGCTGATTGAGGGAACCTTGCGAACTACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGTTACCAAGTTTCCTTAGCAGTGATTGGTACCAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCGACTCAGGCTAGAGCAACACCAAAAGAACACCACGATGGGATTGTTGAGAACTTGGTTGATAA
CTTGAGGGAGTTAGAAAGTGAAAATCTCTTTGACCAGATTCAAATTTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAACTGCTGAAGGTTCCGCAGCAGAAGTGCTACAAGAATGCCTATTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGGTG
AAGGAGAGTGAACTCCTACTTAAGGAATTACTTGAGAAAAATAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT206093 WP_001285585.1 NZ_CP076646:c1838141-1837773 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT206093 NZ_CP102137:640085-640561 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCCTGAGTCGCTACGAAAATGGTACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACACCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCAAAGCTTTATAGATACCAGGATAGTCAAGATATTGTTTTTGATGATGA
ATCTAATCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATCAATACGAAAATTTACCTTGTCGCTACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGATGGTATAGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References