Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 882199..882853 Replicon chromosome
Accession NZ_CP076646
Organism Escherichia coli strain GD33

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag KP013_RS04345 Protein ID WP_000244777.1
Coordinates 882446..882853 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KP013_RS04340 Protein ID WP_000354046.1
Coordinates 882199..882465 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP013_RS04315 (877368) 877368..878111 + 744 WP_000951964.1 SDR family oxidoreductase -
KP013_RS04320 (878168) 878168..879601 - 1434 WP_063502079.1 6-phospho-beta-glucosidase BglA -
KP013_RS04325 (879646) 879646..879957 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
KP013_RS04330 (880121) 880121..880780 + 660 WP_000250274.1 hemolysin III family protein -
KP013_RS04335 (880976) 880976..881956 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
KP013_RS04340 (882199) 882199..882465 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KP013_RS04345 (882446) 882446..882853 + 408 WP_000244777.1 protein YgfX Toxin
KP013_RS04350 (882893) 882893..883414 - 522 WP_001055874.1 flavodoxin FldB -
KP013_RS04355 (883526) 883526..884422 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KP013_RS04360 (884447) 884447..885157 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KP013_RS04365 (885163) 885163..886896 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T206090 WP_000244777.1 NZ_CP076646:882446-882853 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T206090 NZ_CP102136:c2219608-2219351 [Streptococcus suis]
ATGCGAATTCATTTCACAGAGGATGCCTGGGAAGACTATCTTTATTGGCAAGGCCAGGACAAGAAAACACTCAAGCGAAT
CAATAAGATTATCAAGGATATGCAACGACACCCGTTTGAAGGTATTGCCAAGCCAGAACCTTTGAAGTATGATTATCAGG
GTGCCTGGTCAAGAAGGATTGATGCGGAGAATCGCTTGATTTATATGGTAGAAGCAGACCAGTTGTATATCTTGTCGTTA
AAGGACCATTATGGGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT206090 WP_000354046.1 NZ_CP076646:882199-882465 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT206090 NZ_CP102136:c2219870-2219610 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTACATGAAAAAGGTCAATGACGAGTTTGAGCCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTGTCAAAGAGTGAGTGGGATAGCTTACAAGAAACCCTTG
CTGTTGCTCGGAACGCCTATCTATCTCAAAAAGTTCTACGTGGTATGGCTCAAGTCAAAGCAGGTCAAACTCAAGAACGC
CATCTGATAGAGGCGGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References