Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 747703..748538 | Replicon | chromosome |
| Accession | NZ_CP076646 | ||
| Organism | Escherichia coli strain GD33 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A7W4PV54 |
| Locus tag | KP013_RS03650 | Protein ID | WP_000854821.1 |
| Coordinates | 747703..748080 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | KP013_RS03655 | Protein ID | WP_032216526.1 |
| Coordinates | 748170..748538 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KP013_RS03615 (742784) | 742784..743383 | + | 600 | WP_001255034.1 | type II secretion system minor pseudopilin GspJ | - |
| KP013_RS03620 (743386) | 743386..744363 | + | 978 | WP_000633209.1 | type II secretion system minor pseudopilin GspK | - |
| KP013_RS03625 (744360) | 744360..745538 | + | 1179 | WP_000094962.1 | type II secretion system protein GspL | - |
| KP013_RS03630 (745540) | 745540..746076 | + | 537 | WP_063091691.1 | GspM family type II secretion system protein YghD | - |
| KP013_RS03635 (746357) | 746357..747199 | - | 843 | WP_001280501.1 | DUF4942 domain-containing protein | - |
| KP013_RS03640 (747284) | 747284..747481 | - | 198 | WP_023563519.1 | DUF957 domain-containing protein | - |
| KP013_RS03645 (747557) | 747557..747706 | - | 150 | Protein_717 | DUF5983 family protein | - |
| KP013_RS03650 (747703) | 747703..748080 | - | 378 | WP_000854821.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| KP013_RS03655 (748170) | 748170..748538 | - | 369 | WP_032216526.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| KP013_RS03660 (748557) | 748557..749201 | - | 645 | Protein_720 | antitoxin of toxin-antitoxin stability system | - |
| KP013_RS03665 (749220) | 749220..749441 | - | 222 | WP_001601167.1 | DUF987 domain-containing protein | - |
| KP013_RS03670 (749510) | 749510..749986 | - | 477 | WP_001186724.1 | RadC family protein | - |
| KP013_RS03675 (750002) | 750002..750487 | - | 486 | WP_032216512.1 | antirestriction protein | - |
| KP013_RS03680 (750579) | 750579..751397 | - | 819 | WP_165473672.1 | DUF932 domain-containing protein | - |
| KP013_RS03685 (751487) | 751487..751720 | - | 234 | WP_001278288.1 | DUF905 family protein | - |
| KP013_RS03690 (751726) | 751726..752403 | - | 678 | WP_001097362.1 | hypothetical protein | - |
| KP013_RS03695 (752522) | 752522..753406 | - | 885 | WP_000010399.1 | 50S ribosome-binding GTPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13930.95 Da Isoelectric Point: 8.5163
>T206089 WP_000854821.1 NZ_CP076646:c748080-747703 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T206089 NZ_CP102136:1245424-1245690 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCCGCTAAGGCTCAAAAGCAAATTCGAAAGTTGGATAAAACCGCTGCAAGTTTGATTTT
GCGGTATCTTTATAAGCATATTGACGGGTGTGACAACCCCAGACAATACGGAAAAGCTTTGACGGCCAATCGTTCGGGCC
AATGGCGCTATCGTATCGGTAATTACAGGGTTATCGTCAGCATTGAAGATGATAAATTGATTGTAACAGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG
TTGAGTTATAAGGTTATTTTGTCCGCTAAGGCTCAAAAGCAAATTCGAAAGTTGGATAAAACCGCTGCAAGTTTGATTTT
GCGGTATCTTTATAAGCATATTGACGGGTGTGACAACCCCAGACAATACGGAAAAGCTTTGACGGCCAATCGTTCGGGCC
AATGGCGCTATCGTATCGGTAATTACAGGGTTATCGTCAGCATTGAAGATGATAAATTGATTGTAACAGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 13810.69 Da Isoelectric Point: 6.2066
>AT206089 WP_032216526.1 NZ_CP076646:c748538-748170 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLLCTVTPCFGARLVQEGNRLHYLVDRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDKLHETNYPDDHNDRLWWGLLCTVTPCFGARLVQEGNRLHYLVDRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT206089 NZ_CP102136:1245195-1245434 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTTTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGCTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGATGAGTACGATGCGCGTGTGGCAGATATTGCTTGGGCAG
AATACCAAGAAGACTTGGCGAATGGAATTGAGCCGATAACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTTTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGCTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGATGAGTACGATGCGCGTGTGGCAGATATTGCTTGGGCAG
AATACCAAGAAGACTTGGCGAATGGAATTGAGCCGATAACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|