Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3147803..3148637 Replicon chromosome
Accession NZ_CP076645
Organism Escherichia coli strain MSI001

Toxin (Protein)


Gene name yeeV Uniprot ID W0S379
Locus tag KP725_RS15370 Protein ID WP_000854808.1
Coordinates 3147803..3148180 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2J4HRK6
Locus tag KP725_RS15375 Protein ID WP_001354276.1
Coordinates 3148269..3148637 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP725_RS15340 (3144472) 3144472..3145176 + 705 WP_001241678.1 leucyl/phenylalanyl-tRNA--protein transferase -
KP725_RS15345 (3145461) 3145461..3145679 + 219 WP_001040187.1 translation initiation factor IF-1 -
KP725_RS15355 (3146170) 3146170..3147012 - 843 WP_089587852.1 DUF4942 domain-containing protein -
KP725_RS15360 (3147109) 3147109..3147306 - 198 WP_000839234.1 DUF957 domain-containing protein -
KP725_RS15365 (3147318) 3147318..3147806 - 489 WP_089587850.1 DUF5983 family protein -
KP725_RS15370 (3147803) 3147803..3148180 - 378 WP_000854808.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KP725_RS15375 (3148269) 3148269..3148637 - 369 WP_001354276.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
KP725_RS15380 (3148687) 3148687..3149331 - 645 WP_000086745.1 hypothetical protein -
KP725_RS15385 (3149350) 3149350..3149571 - 222 WP_089570377.1 DUF987 domain-containing protein -
KP725_RS15390 (3149640) 3149640..3150116 - 477 WP_216684054.1 RadC family protein -
KP725_RS15395 (3150132) 3150132..3150611 - 480 WP_089578132.1 antirestriction protein -
KP725_RS15400 (3150705) 3150705..3150950 - 246 WP_089578131.1 antirestriction protein -
KP725_RS15405 (3150950) 3150950..3151768 - 819 WP_201490963.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13909.93 Da        Isoelectric Point: 7.9085

>T206081 WP_000854808.1 NZ_CP076645:c3148180-3147803 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T206081 NZ_CP102108:c3091937-3091284 [Aeromonas veronii]
ATGGCCTATGACTATAGCCAGAGCCTGAATCCGCAGAAGGCGCTGATATTCCGGATCGTGCATCGGGATAACCTGGAATG
GATCCTGACCCATGGCCTGTGGGCGGGGAATGGTCAGCAGCAAAGCCCGCACTGGGTGCATATCGGGTTGCCGGAGCTGA
TTGCCAAGCGCGCGCGCCATCCGGTGCCGCTGGCTCCTTACGGCGTGTTGAATGACTATGTGCCCTTCTACTTCACGCCG
TTTTCTCCCATGCTCAGCAATATTCACTCAGGGCGCGGTGTTCCCCAGCGTGAAAATGATGAAATCTTGATCCTGGTTTC
CAGCCTGCATCGCATGGCTGAATTGGGGCTACCGTTTGTGTTTACCGATAGCCATGCCTATTACCAGTGGGCCAATTTCT
ATGTCGATCTTGGCGATCTGGGGCGGATTGACTGGCCACTGTTGCAGCGCCGTGACTTCAAGCGTGATGCGGACGATTTG
AGCAAGCTGGAACGCTATCAGGCCGAGGCCTTGATCCATCAACATTGTCCCATCGAGGCGTTGCTGGGCGTGGTGTGTTA
CAACGAAGAGATAAAGAACCGCGTGGAACAATGCATGAATCGGGTCGGGGTCGCGCGCCCCGTCTATGTCCGTGATGGGT
GGTATTTCAGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13649.47 Da        Isoelectric Point: 7.0261

>AT206081 WP_001354276.1 NZ_CP076645:c3148637-3148269 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLSSCGYVYLAVYPTPKMKN

Download         Length: 369 bp

>AT206081 NZ_CP102108:c3091287-3090223 [Aeromonas veronii]
ATGATTCGATATACAACAGGCAATCTGCTGGATGCTCCGGTGGAAGCGCTGGTGAATACCGTCAACACCGTCGGTGTCAT
GGGCAAGGGGATCGCCTTGATGTTCAAGGAGCGGTTCCCGGCCAATATGCGCGCCTATGCCGAGGCGTGCAAACAGGGTG
ATGTCGTCACCGGCAAGATGTTTATTACCCAGACGGGTGAGCTGCTGGGGCCGCGCTGGATCGTGAATTTTCCGACCAAA
CAGCACTGGCGCAATCCGGCACAGATGGCGTGGATCCAGGATGGTTTGCAGGATCTACGGGCCTGGTTACAGGCGCAGCA
GGTCTCTTCGATTGCCATTCCGCCGCTGGGGGCTGGCAACGGTGGTCTGCCTTGGCCAGAGGTCAAACAGGCGATTGAAA
CGGCACTGGGCGATCTGGATATCGATATCCTGCTCTATGAGCCCAGTAGCCAATACCAAAATGTGGCCAAGCGCGGCGGG
GTGGCGGAGCTGACTCCGGCTCGGGCCCTGATTGCTGAACTGGTACGTCGCTACTGGTTTTTAGGGATGGAGTGCAGCTT
GCTGGAGATCCAGAAGCTGGCCTGGTTTCTGGCTCGGGTCATTGGCCGCAACCCGCTGGGGGATCCGCTGCAGTTGCAGT
TTAAGGCCCATCGTTATGGCCCTTATGCCAACAATCTGACCCATCTGCTCAATGCGATGGACGGCAGTTATCTGCAGTCC
GACAAGCGCATCCCGGATAGCAAGCCGTTTGATGTCATCTGGTTTAATGAGGCTAAAAAACAAGAGCTTGCCGTTTATCT
CCAGACCGAGGCCAAAGCATTTTTACCGATACTGGAGCAGACGACCGCGTTAATCGATGGTTTTGAGTCGCCCTATGGCA
TGGAGTTATTGGCCACGGTTGATTGGTTGATCGCCGAAGAGGGCTGTGCGCCGACGCTGAGCGCGCTGCGCGAGGGGTTG
CACCGCTGGCCTGCGGGAACCCCGTGGGGTGAGCGTAAGGCGCGGCTGTTTGATGATCGCAGCCTGCAGATCGCCTTGAC
CCGTTTGCAGCAGGGATTGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W0S379

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4HRK6

References