Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 945792..946446 Replicon chromosome
Accession NZ_CP076645
Organism Escherichia coli strain MSI001

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag KP725_RS04565 Protein ID WP_000244777.1
Coordinates 946039..946446 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KP725_RS04560 Protein ID WP_000354046.1
Coordinates 945792..946058 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP725_RS04535 (940961) 940961..941704 + 744 WP_000951962.1 SDR family oxidoreductase -
KP725_RS04540 (941761) 941761..943194 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
KP725_RS04545 (943239) 943239..943550 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
KP725_RS04550 (943714) 943714..944373 + 660 WP_000250274.1 hemolysin III family protein -
KP725_RS04555 (944569) 944569..945549 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
KP725_RS04560 (945792) 945792..946058 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KP725_RS04565 (946039) 946039..946446 + 408 WP_000244777.1 protein YgfX Toxin
KP725_RS04570 (946486) 946486..947007 - 522 WP_001055874.1 flavodoxin FldB -
KP725_RS04575 (947119) 947119..948015 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KP725_RS04580 (948040) 948040..948750 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KP725_RS04585 (948756) 948756..950489 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T206068 WP_000244777.1 NZ_CP076645:946039-946446 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T206068 NZ_CP102094:c1886957-1886622 [Streptococcus suis]
TTGGATAAGTACCAAGTAAACCTACCTCTAGCCATATACGAGGAACTAGCAGGCATTCGTAGCTATATCAGCGAAGAGTT
AAAAAGCCCTGATGCAGCGGACAAAAAAATCCAAGAGCTAATAGCAGGACTTAGAAGCCTTGAAATCTTCCCAGAGCGAG
GTTTTAACGTAGATGAACGCTCTAAAAAAGGACCGCTAGTCCCAGGTCATCTGACGCGAGGACTGCCCATCAAAAAGGAT
TATATAGCTATTTATAACATTGATGAAGCACAAAAGGTCGTAAACGTTCGCTATCTTGTCGCAAGCAAGAGCGACTATAT
GAGATTGTTCAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT206068 WP_000354046.1 NZ_CP076645:945792-946058 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT206068 NZ_CP102094:c1887237-1886950 [Streptococcus suis]
ATGGCCTTAACAGCTGAAAAGAAATTGATTAACTTTCAATCAGAAAAATCACTTGTAGAAGAAGCAAAAGAGGTCTTGGC
AAGTCAAAATATGACTATGACACAAGCCCTCAACCTGTTTCTCAAAAATATTGTAGTAACAGGAGAAATTGGGCTTAAAA
GTGAAGAAGAACTGGAAAAAGAGCGACTATTTGCCGAACTGCAAGCAGAAGTGATGAAAAATGTAGCTGAAATGAATGCG
GGCAACTATCTATCATTGGACGAAATGGAGACCAAGCTCTTTGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References