Detailed information of TA system TA206063

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1581844..1583405
• Replicon: chromosome
• Accession: NZ_CP076643
• Organism: Vibrio ostreae strain OG9-811

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A975UC62
• Locus tag: KNV97_RS13225
• Protein ID: WP_072603483.1
• Coordinates: 1581844..1583172 (-)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KNV97_RS13230
• Protein ID: WP_017788886.1
• Coordinates: 1583166..1583405 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KNV97_RS13210 (KNV97_13210)	1577206..1578192	+	987	WP_218563435.1	LacI family DNA-binding transcriptional regulator	-
KNV97_RS13215 (KNV97_13215)	1578388..1579920	+	1533	WP_218563317.1	hypothetical protein	-
KNV97_RS13220 (KNV97_13220)	1580325..1581650	+	1326	WP_074544455.1	site-specific integrase	-
KNV97_RS13225 (KNV97_13225)	1581844..1583172	-	1329	WP_072603483.1	type II toxin-antitoxin system HipA family toxin	Toxin
KNV97_RS13230 (KNV97_13230)	1583166..1583405	-	240	WP_017788886.1	helix-turn-helix domain-containing protein	Antitoxin
KNV97_RS13235 (KNV97_13235)	1583993..1585438	+	1446	WP_218563318.1	SIR2 family protein	-
KNV97_RS13240 (KNV97_13240)	1585450..1585950	+	501	WP_218563319.1	TIR domain-containing protein	-
KNV97_RS13245 (KNV97_13245)	1586225..1587208	+	984	WP_218563320.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1581844..1593374	11530

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (151-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-55)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 49648.01 Da
• Isoelectric Point: 9.1007

>T206063 WP_072603483.1 NZ_CP076643:c1583172-1581844 [Vibrio ostreae]
MVNRLHAYMNGVKVGVLEKRTNGAHVFTYDSDWVSAPNGRPISLSMPLRKGMYTGSEVINFFDNLLPDNQQIRDRIAARY
KADTKQPFDLLAKVGRDAVGAITLVPEGFDVDDHRVITAKALSEKELVRILKGYMEDAPLGMLKEEDDFRISIAGAQEKT
ALLFHDGRWMLPQGMTPTTHIIKLPIGEIVSQNNVIDLSASVDNELICMRLAKAFGIQTANCDIIRAGDVRALSVERFDR
KLSSDNSYYLRLPHEDFCQAKGIPSARKYEIDGGIGIEESIDILRYSYEINDTVTFARSQILFWLLAAIDGHGKNFSVSI
AASGRYQLAPLYDIISAHPLAGGRGLSERKIKMAMSLRGTSGRKWKWHQLQPRHFEDTFHTMNVPNIRREKVRLLLDEFE
STARAVIDSVGNSLPTDINESVRDKIFNGVLKTVKKIQLTKK

Nucleotide

• Length: 1329 bp

>T206063 NZ_CP102089:1880880-1881341 [Staphylococcus capitis subsp. capitis]
ATGGGGTTATATGAAAAAATGTTAATAGAGCATGACTATATAGAAATCAGAGAAACAGATGTTATGCCTAATGACTTACA
CGGTTTATGGTTAGGCGATTTAATTCTAATTAAACGCAACCTTTCCGAAACACGCAAAGCCGAAGTGCTATACGAAGAAC
TAGCACATCACAAACTTACATATGGAAACATCTTAGATCAATCTAAAGATATAAACCGCAAATTTGAAAACTACGCTAGG
CGTTACGGATATGAAGCTGCTCTACCTTTACGCATTATTGTGGAGGCGCATAACTATGGTGTTAATAACTTATATGAACT
AGCTGAATATGTTCAATTAAGTGAAGAACACGTATTAGAAATATTGAATCATTACAAAAATAAATATGGTATTGGAACTC
ACTACGGAGAATACTTAATTACATTTGATCCGTTGAGGGTTTTTAAATATAAAGAAATATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8717.96 Da
• Isoelectric Point: 7.2036

>AT206063 WP_017788886.1 NZ_CP076643:c1583405-1583166 [Vibrio ostreae]
MLVNTPTALGNALREARKDNGLKQTDLGLRQATVSNFESNPEKSTIETLFKLLSINGLEMHIVPKGKHITETKGAVDEW

Nucleotide

• Length: 240 bp

>AT206063 NZ_CP102089:1880539-1880868 [Staphylococcus capitis subsp. capitis]
ATGAGAAATAATGATGAAATAATCACAATAATTAAATCAGCTATGAAAGAACAAGATATGTCACTTAGTGAATTGGCTCG
TCGTGTTGGAGTTGCTAAATCTGCTGTATCACGTTATTTAAATTTAACTAGAGAATTCCCATTAAATCGTTCAGAAGATT
TTGCAAAAGCACTTAGTATCAGTACAGAATATTTACTTGGTTTTGATAAAAGTGAACAACAACATGAACAACCACAACAT
CGTGCAGCTCATCTTGAAGGCGAATTAACTGATGACGAATGGCAACGAGTTTTAGATTATGCTGATTTTATAAGAAGTAA
ACGTAAATAA