Detailed information of TA system TA206061

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2579877..2580421
• Replicon: chromosome
• Accession: NZ_CP076628
• Organism: Xanthomonas arboricola pv. pruni strain IVIA 2626.1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KP026_RS11145
• Protein ID: WP_228960823.1
• Coordinates: 2580152..2580421 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2N7V9L6
• Locus tag: KP026_RS11140
• Protein ID: WP_016902922.1
• Coordinates: 2579877..2580134 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP026_RS11125 (KP026_11095)	2574985..2576493	-	1509	WP_043087410.1	ribonuclease H-like domain-containing protein	-
KP026_RS11130 (KP026_11100)	2576490..2578985	-	2496	WP_043087409.1	DEAD/DEAH box helicase	-
KP026_RS11135 (KP026_11105)	2579159..2579821	+	663	WP_039511099.1	hemolysin III family protein	-
KP026_RS11140 (KP026_11110)	2579877..2580134	+	258	WP_016902922.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KP026_RS11145 (KP026_11115)	2580152..2580421	+	270	WP_228960823.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KP026_RS11150 (KP026_11120)	2580540..2581061	-	522	WP_051633992.1	hypothetical protein	-
KP026_RS11155 (KP026_11125)	2581232..2581585	-	354	WP_081327586.1	helix-turn-helix domain-containing protein	-
KP026_RS11160 (KP026_11130)	2581618..2581824	+	207	WP_223571151.1	hypothetical protein	-
KP026_RS11165 (KP026_11135)	2581984..2583075	-	1092	WP_039511112.1	ATP-grasp fold amidoligase family protein	-
KP026_RS11170 (KP026_11140)	2583533..2584246	+	714	WP_039511101.1	hypothetical protein	-
KP026_RS11175 (KP026_11145)	2584257..2585150	-	894	WP_043087408.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2579877..2591487	11610

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10221.75 Da
• Isoelectric Point: 10.1539

>T206061 WP_228960823.1 NZ_CP076628:2580152-2580421 [Xanthomonas arboricola pv. pruni]
VADLDAIADYIALEDAAAAAALVRRVFAHVEQLAEHPESGSRPQELKRSRYRQIVEPPCRVFYRVDGQRVVVVHVMRSER
LLRKNRLSR

Nucleotide

• Length: 270 bp

>T206061 NZ_CP102089:860867-861223 [Staphylococcus capitis subsp. capitis]
ATGATTAGAAGAGGCGATGTTTACTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTTGT
AATTATACAAAATGATACTGGTAATAAATATAGTCCAACTGTCATAGTTGCTGCTATTACAGGTAGGATTAATAAAGCGA
AGATACCAACCCATGTAGAAATTGAAAAGAAAAAATATAAGTTAGATAAAGACTCTGTTATCTTACTTGAACAAATTAGA
ACACTAGATAAAAAACGTTTAAAAGAGAAGTTGACCTATTTGTCTGAAAGTAAGATGAAGGAAGTTGACAACGCCCTAGA
TATCAGTCTAGGATTACATAATTTTGACCATCAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9704.23 Da
• Isoelectric Point: 8.6056

>AT206061 WP_016902922.1 NZ_CP076628:2579877-2580134 [Xanthomonas arboricola pv. pruni]
MRTELVTTLKRQATELLADVERDKEPILITQHGLPSAYLVDVASYERMQQRMAILEGIARGEMAVAEGRSLSHEQAKQRL
ARWLK

Nucleotide

• Length: 258 bp

>AT206061 NZ_CP102089:860700-860870 [Staphylococcus capitis subsp. capitis]
ATGTTATCTTTTAATCAATCTAGGAGTCACAGTCTTGAACAATCATTAAAAGAAGGCTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACGGAAGCTTTTCCCATCGAATGTGAAGCTTGCGATTGTAATGAAACATATCTTACTTCTAACTCTA
AGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2N7V9L6