Detailed information of TA system TA206058

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3937897..3938714
• Replicon: chromosome
• Accession: NZ_CP076623
• Organism: Morganella morganii strain CTX51T

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: KQH80_RS18735
• Protein ID: WP_230059705.1
• Coordinates: 3937897..3938403 (-)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: J7TDK6
• Locus tag: KQH80_RS18740
• Protein ID: WP_004236533.1
• Coordinates: 3938406..3938714 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQH80_RS18695 (KQH80_18690)	3933073..3933696	-	624	WP_046891924.1	thiol:disulfide interchange protein DsbA	-
KQH80_RS18700 (KQH80_18695)	3933715..3934710	-	996	WP_230059701.1	serine/threonine protein kinase	-
KQH80_RS18705 (KQH80_18700)	3934710..3934979	-	270	WP_046891954.1	YihD family protein	-
KQH80_RS18710	3935232..3935804	+	573	Protein_3642	molybdenum cofactor guanylyltransferase MobA	-
KQH80_RS18715	3935811..3936329	+	519	WP_230061381.1	molybdopterin-guanine dinucleotide biosynthesis protein MobB	-
KQH80_RS18720 (KQH80_18710)	3936540..3936842	+	303	WP_004240743.1	HdeA/HdeB family chaperone	-
KQH80_RS18725 (KQH80_18715)	3936970..3937491	+	522	WP_230059704.1	isopentenyl-diphosphate Delta-isomerase	-
KQH80_RS18730 (KQH80_18720)	3937488..3937889	+	402	WP_107679924.1	GNAT family N-acetyltransferase	-
KQH80_RS18735 (KQH80_18725)	3937897..3938403	-	507	WP_230059705.1	GNAT family N-acetyltransferase	Toxin
KQH80_RS18740 (KQH80_18730)	3938406..3938714	-	309	WP_004236533.1	DUF1778 domain-containing protein	Antitoxin
KQH80_RS18745 (KQH80_18735)	3938847..3938963	-	117	WP_230059706.1	hypothetical protein	-
KQH80_RS18750 (KQH80_18740)	3938967..3939236	+	270	Protein_3650	transposase	-
KQH80_RS18755 (KQH80_18745)	3939251..3939343	-	93	Protein_3651	transposase	-
KQH80_RS18760 (KQH80_18750)	3939658..3940443	+	786	WP_230059707.1	hypothetical protein	-
KQH80_RS18765 (KQH80_18755)	3940445..3942709	+	2265	WP_230059708.1	UvrD-helicase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (21-94)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18481.36 Da
• Isoelectric Point: 10.2370

>T206058 WP_230059705.1 NZ_CP076623:c3938403-3937897 [Morganella morganii]
MNLTAPEPLQQHHDFTAFQSGEGSLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILLGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE

Nucleotide

• Length: 507 bp

>T206058 NZ_CP102087:2208101-2208370 [Staphylococcus capitis subsp. capitis]
ATGAGTAAGTTTAGTGTAGCTTTTACAGCTCAAGCATTTAAAGATTATCAATATTGGCAACAACACAATCAAAATTATTT
TAAAAAAGTGAATTCTTTACTTAAAAGTATTGCAAGAGATGGTTGTGTTGATGGTATTGGAAAACCAGAAGCATTAAAAG
GAAACTACGAAGGCTATTTCAGTAGAAGAGTTTCAATAGAACAACGATTAATATACAAAATTAAGGATGATTCAATATTC
GTAGTGTCTTGCAGATTTCATTATCAATAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11499.15 Da
• Isoelectric Point: 8.6397

>AT206058 WP_004236533.1 NZ_CP076623:c3938714-3938406 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Nucleotide

• Length: 309 bp

>AT206058 NZ_CP102087:2207851-2208108 [Staphylococcus capitis subsp. capitis]
ATGCCTTCAGTTAATTATTCAAACGCTAGACAGAATTTCAAAGAACTTATTACTAAAGTGAACGAGGATAGTGTGGCTTA
CACTATTACGACAAAGGAAAATGAAAATGCAGTGATTTTAGCTGAAAAGGATTATAATGCGATGTTGGAAACGATGTACC
TTCTATCCAATCTCGCTAATGTGTCTCACTTAAATCAATCAATTATGGAATTGAATCATAACCAAACAATTACAATAGAG
ATTGATGATAATGAGTAA

Structures

Antitoxin

• AlphaFold DB: J7TDK6