Detailed information of TA system TA206056

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1180431..1181223
• Replicon: chromosome
• Accession: NZ_CP076623
• Organism: Morganella morganii strain CTX51T

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A7T9XK14
• Locus tag: KQH80_RS05290
• Protein ID: WP_024474879.1
• Coordinates: 1180816..1181223 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: KQH80_RS05285
• Protein ID: WP_046894613.1
• Coordinates: 1180431..1180667 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQH80_RS05270 (KQH80_05265)	1175498..1178374	+	2877	WP_230060714.1	aminomethyl-transferring glycine dehydrogenase	-
KQH80_RS05275 (KQH80_05270)	1178435..1179040	-	606	WP_230060715.1	HD domain-containing protein	-
KQH80_RS05280 (KQH80_05275)	1179119..1180102	-	984	WP_230060717.1	tRNA-modifying protein YgfZ	-
KQH80_RS05285 (KQH80_05280)	1180431..1180667	+	237	WP_046894613.1	succinate dehydrogenase assembly factor 2	Antitoxin
KQH80_RS05290 (KQH80_05285)	1180816..1181223	+	408	WP_024474879.1	protein YgfX	Toxin
KQH80_RS05295 (KQH80_05290)	1181229..1181747	-	519	WP_107678965.1	flavodoxin FldB	-
KQH80_RS05300 (KQH80_05295)	1181881..1182795	+	915	WP_046894461.1	site-specific tyrosine recombinase XerD	-
KQH80_RS05305 (KQH80_05300)	1182808..1183500	+	693	WP_052926858.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KQH80_RS05310 (KQH80_05305)	1183523..1185256	+	1734	WP_230060719.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (1-63)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15561.33 Da
• Isoelectric Point: 11.3804

>T206056 WP_024474879.1 NZ_CP076623:1180816-1181223 [Morganella morganii]
VVLWKSVLRVSFKTQVFSTLIYGVLALSVLFAPWPGRTSFIWLPLTLLLIAGWGRTQYKISKRAGPASLQNHNRILWRKS
EWEITKPPYITRLGIRLHLRSLTSGRQKYLWIASDSVPAEAWSSLNQLLLQYPDI

Nucleotide

• Length: 408 bp

>T206056 NZ_CP102087:c1642773-1642417 [Staphylococcus capitis subsp. capitis]
ATGATTAGAAGAGGCGATGTTTACTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTTGT
AATTATACAAAATGATACTGGTAATAAATATAGTCCAACTGTCATAGTTGCTGCTATTACAGGTAGGATTAATAAAGCGA
AGATACCAACCCATGTAGAAATTGAAAAGAAAAAATATAAGTTAGATAAAGACTCTGTTATCTTACTTGAACAAATTAGA
ACACTAGATAAAAAACGTTTAAAAGAGAAGTTGACCTATTTGTCTGAAAGTAAGATGAAGGAAGTTGACAACGCCCTAGA
TATCAGTCTAGGATTACATAATTTTGACCATCAATGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9282.48 Da
• Isoelectric Point: 4.1959

>AT206056 WP_046894613.1 NZ_CP076623:1180431-1180667 [Morganella morganii]
MRELDIAIMPFFQHEYDTLTDGQKQDFIQLLTCPDPDLFNWLMNKGRPDDEALYQIIRLIQERNQARMAAQNSAYYPD

Nucleotide

• Length: 237 bp

>AT206056 NZ_CP102087:c1642940-1642770 [Staphylococcus capitis subsp. capitis]
ATGTTATCTTTTAATCAATCTAGGAGTCACAGTCTTGAACAATCATTAAAAGAAGGCTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACGGAAGCTTTTCCCATCGAATGTGAAGCTTGCGATTGTAATGAAACATATCTTACTTCTAACTCTA
AGAATGAATGA

Structures

Toxin

• AlphaFold DB: A0A7T9XK14