Detailed information of TA system TA206052

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1965920..1966555
• Replicon: chromosome
• Accession: NZ_CP076607
• Organism: Paenibacillus sophorae strain DSM 23020

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A0F7CHC6
• Locus tag: KP014_RS09165
• Protein ID: WP_025691534.1
• Coordinates: 1966205..1966555 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: KP014_RS09160
• Protein ID: WP_036587267.1
• Coordinates: 1965920..1966201 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP014_RS09135 (KP014_09135)	1961482..1961823	-	342	WP_036587244.1	cupin domain-containing protein	-
KP014_RS28705	1961862..1961993	-	132	WP_246590682.1	hypothetical protein	-
KP014_RS09145 (KP014_09145)	1962501..1962971	+	471	WP_036587243.1	RpiB/LacA/LacB family sugar-phosphate isomerase	-
KP014_RS09150 (KP014_09150)	1963210..1964298	+	1089	WP_036587242.1	outer membrane lipoprotein-sorting protein	-
KP014_RS09155 (KP014_09155)	1964523..1965725	+	1203	WP_036587240.1	alanine racemase	-
KP014_RS09160 (KP014_09160)	1965920..1966201	+	282	WP_036587267.1	CopG family ribbon-helix-helix protein	Antitoxin
KP014_RS09165 (KP014_09165)	1966205..1966555	+	351	WP_025691534.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
KP014_RS09170 (KP014_09170)	1966755..1968944	+	2190	WP_090834055.1	Tex family protein	-
KP014_RS09175 (KP014_09175)	1969088..1970071	-	984	WP_036600680.1	S-layer homology domain-containing protein	-
KP014_RS09180 (KP014_09180)	1970323..1971069	+	747	WP_036600678.1	DeoR/GlpR family DNA-binding transcription regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1955367..1968944	13577

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-45)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12796.68 Da
• Isoelectric Point: 5.1171

>T206052 WP_025691534.1 NZ_CP076607:1966205-1966555 [Paenibacillus sophorae]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDASSHGFDRDSVILLEQV
RTIDKQRLTDKITHLDDETMKKVDDSLQISLGLIDF

Nucleotide

• Length: 351 bp

>T206052 NZ_CP102086:3890639-3891022 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACATTTCCTAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
GGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10685.38 Da
• Isoelectric Point: 7.1666

>AT206052 WP_036587267.1 NZ_CP076607:1965920-1966201 [Paenibacillus sophorae]
MANLHNTKRIMISLPDHLLQEVDGIVQMENSNRSELIRQAMKLYLSERRKRSIRESMQRGYMEMAKINLTMACEAFLAEE
DADSTLGRLVSGV

Nucleotide

• Length: 282 bp

>AT206052 NZ_CP102086:3890421-3890642 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Structures

Toxin

• AlphaFold DB: A0A0F7CHC6