Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1965920..1966555 Replicon chromosome
Accession NZ_CP076607
Organism Paenibacillus sophorae strain DSM 23020

Toxin (Protein)


Gene name mazF Uniprot ID A0A0F7CHC6
Locus tag KP014_RS09165 Protein ID WP_025691534.1
Coordinates 1966205..1966555 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KP014_RS09160 Protein ID WP_036587267.1
Coordinates 1965920..1966201 (+) Length 94 a.a.

Genomic Context

KP014_RS09145KP014_RS09150KP014_RS09155KP014_RS09160KP014_RS09165KP014_RS09170KP014_RS09180KP014_RS09135KP014_RS28705KP014_RS09175
Location: 1962501..1962971 (471 bp)
Type: Others
Protein ID: WP_036587243.1
Location: 1963210..1964298 (1089 bp)
Type: Others
Protein ID: WP_036587242.1
Location: 1964523..1965725 (1203 bp)
Type: Others
Protein ID: WP_036587240.1
Location: 1965920..1966201 (282 bp)
Type: Antitoxin
Protein ID: WP_036587267.1
Location: 1966205..1966555 (351 bp)
Type: Toxin
Protein ID: WP_025691534.1
Location: 1966755..1968944 (2190 bp)
Type: Others
Protein ID: WP_090834055.1
Location: 1970323..1971069 (747 bp)
Type: Others
Protein ID: WP_036600678.1
Location: 1961482..1961823 (342 bp)
Type: Others
Protein ID: WP_036587244.1
Location: 1961862..1961993 (132 bp)
Type: Others
Protein ID: WP_246590682.1
Location: 1969088..1970071 (984 bp)
Type: Others
Protein ID: WP_036600680.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KP014_RS09135 (KP014_09135)1961482..1961823-342WP_036587244.1cupin domain-containing protein-
KP014_RS287051961862..1961993-132WP_246590682.1hypothetical protein-
KP014_RS09145 (KP014_09145)1962501..1962971+471WP_036587243.1RpiB/LacA/LacB family sugar-phosphate isomerase-
KP014_RS09150 (KP014_09150)1963210..1964298+1089WP_036587242.1outer membrane lipoprotein-sorting protein-
KP014_RS09155 (KP014_09155)1964523..1965725+1203WP_036587240.1alanine racemase-
KP014_RS09160 (KP014_09160)1965920..1966201+282WP_036587267.1CopG family ribbon-helix-helix proteinAntitoxin
KP014_RS09165 (KP014_09165)1966205..1966555+351WP_025691534.1type II toxin-antitoxin system PemK/MazF family toxinToxin
KP014_RS09170 (KP014_09170)1966755..1968944+2190WP_090834055.1Tex family protein-
KP014_RS09175 (KP014_09175)1969088..1970071-984WP_036600680.1S-layer homology domain-containing protein-
KP014_RS09180 (KP014_09180)1970323..1971069+747WP_036600678.1DeoR/GlpR family DNA-binding transcription regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1955367..196894413577


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12796.68 Da        Isoelectric Point: 5.1171

>T206052 WP_025691534.1 NZ_CP076607:1966205-1966555 [Paenibacillus sophorae]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDASSHGFDRDSVILLEQV
RTIDKQRLTDKITHLDDETMKKVDDSLQISLGLIDF

Download         Length: 351 bp

>T206052 NZ_CP102086:3890639-3891022 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACATTTCCTAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
GGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10685.38 Da        Isoelectric Point: 7.1666

>AT206052 WP_036587267.1 NZ_CP076607:1965920-1966201 [Paenibacillus sophorae]
MANLHNTKRIMISLPDHLLQEVDGIVQMENSNRSELIRQAMKLYLSERRKRSIRESMQRGYMEMAKINLTMACEAFLAEE
DADSTLGRLVSGV

Download         Length: 282 bp

>AT206052 NZ_CP102086:3890421-3890642 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F7CHC6

Antitoxin

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Source
ID
Structure
No matching records found

References