Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4125417..4126036 Replicon chromosome
Accession NZ_CP076605
Organism Raoultella ornithinolytica strain XF201

Toxin (Protein)


Gene name Hha Uniprot ID A0A514EV16
Locus tag KP007_RS19440 Protein ID WP_004858783.1
Coordinates 4125818..4126036 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A514EV88
Locus tag KP007_RS19435 Protein ID WP_004858785.1
Coordinates 4125417..4125791 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP007_RS19425 (KP007_19425) 4120528..4121721 + 1194 WP_004858789.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KP007_RS19430 (KP007_19430) 4121744..4124890 + 3147 WP_004858787.1 multidrug efflux RND transporter permease subunit AcrB -
KP007_RS19435 (KP007_19435) 4125417..4125791 + 375 WP_004858785.1 Hha toxicity modulator TomB Antitoxin
KP007_RS19440 (KP007_19440) 4125818..4126036 + 219 WP_004858783.1 HHA domain-containing protein Toxin
KP007_RS19445 (KP007_19445) 4126188..4126754 + 567 WP_004858781.1 maltose O-acetyltransferase -
KP007_RS26770 4126726..4126860 - 135 WP_223306663.1 hypothetical protein -
KP007_RS19450 (KP007_19450) 4126854..4127324 + 471 WP_004858780.1 YlaC family protein -
KP007_RS19455 (KP007_19455) 4127299..4128750 - 1452 WP_104896844.1 PLP-dependent aminotransferase family protein -
KP007_RS19460 (KP007_19460) 4128854..4129564 + 711 WP_015585015.1 GNAT family protein -
KP007_RS19465 (KP007_19465) 4129561..4129701 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
KP007_RS19470 (KP007_19470) 4129704..4129964 - 261 WP_004858777.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8570.90 Da        Isoelectric Point: 7.9907

>T206049 WP_004858783.1 NZ_CP076605:4125818-4126036 [Raoultella ornithinolytica]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T206049 NZ_CP102086:c233042-232656 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14411.19 Da        Isoelectric Point: 4.8989

>AT206049 WP_004858785.1 NZ_CP076605:4125417-4125791 [Raoultella ornithinolytica]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT206049 NZ_CP102086:c232663-232343 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGAATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCCGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EV16

Antitoxin

Source ID Structure
AlphaFold DB A0A514EV88

References