Detailed information of TA system TA206048

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2746346..2747949
• Replicon: chromosome
• Accession: NZ_CP076605
• Organism: Raoultella ornithinolytica strain XF201

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KP007_RS13095
• Protein ID: WP_152308667.1
• Coordinates: 2746346..2747677 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A808YAX5
• Locus tag: KP007_RS13100
• Protein ID: WP_032717448.1
• Coordinates: 2747677..2747949 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP007_RS13080 (KP007_13080)	2742220..2743134	-	915	WP_015584333.1	branched-chain amino acid ABC transporter permease	-
KP007_RS13085 (KP007_13085)	2743234..2744292	-	1059	WP_162180097.1	branched-chain amino acid ABC transporter substrate-binding protein	-
KP007_RS13090 (KP007_13090)	2745007..2746413	+	1407	WP_015584334.1	glycoside hydrolase family 10 protein	-
KP007_RS13095 (KP007_13095)	2746346..2747677	-	1332	WP_152308667.1	type II toxin-antitoxin system HipA family toxin	Toxin
KP007_RS13100 (KP007_13100)	2747677..2747949	-	273	WP_032717448.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KP007_RS13105 (KP007_13105)	2748153..2748707	-	555	WP_103072880.1	RNA polymerase sigma factor	-
KP007_RS13110 (KP007_13110)	2748713..2749138	-	426	WP_103072881.1	hypothetical protein	-
KP007_RS13115 (KP007_13115)	2749272..2750225	-	954	WP_152308666.1	hypothetical protein	-
KP007_RS13120 (KP007_13120)	2750439..2751071	-	633	WP_048023555.1	class I SAM-dependent methyltransferase	-
KP007_RS13125 (KP007_13125)	2751091..2752332	-	1242	WP_152308665.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 49357.68 Da
• Isoelectric Point: 6.7012

>T206048 WP_152308667.1 NZ_CP076605:c2747677-2746346 [Raoultella ornithinolytica]
MTTLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDEAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENAPRGALSWEPLDNHALDALLTAYQSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPPASIIQTASIRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSIKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLKLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFAQQQMLEILRYFVDNVP
RAVEAVKGTLPPDFSQPVYEAITDRLLWVHSRLQNAMAASPSG

Nucleotide

• Length: 1332 bp

>T206048 NZ_CP102085:1963857-1964132 [Mycoavidus sp. SF9855]
ATGGAAGTAAAATGGACGAGTAAGGCGCTTGCAGAGTTAGGGCGATTGTATGAGTTTTTAGCCTCGGTTAGTCAATCAGC
TGCTGCACATGTGATCCAGTCTCTCACTGCTGCACTGGCACGCTTGCAAGTGAATCCTCGTATAGGAGAGAGGTTTGAAG
AATTTGACCCACGAGAGGTTCGCAGAATTTTTGTAGGGCATTATGAAATGCGCTATGAAATCCAGGGCTCCACGCTCTAT
ATATTGCGTCTTTGGCATACGCGTGAAGACCATTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10365.71 Da
• Isoelectric Point: 5.7971

>AT206048 WP_032717448.1 NZ_CP076605:c2747949-2747677 [Raoultella ornithinolytica]
MSPSPTIYSPVQLANYLKLVRQKNQWTQSELAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDTDD
NRDNPRDLEW

Nucleotide

• Length: 273 bp

>AT206048 NZ_CP102085:1963708-1963857 [Mycoavidus sp. SF9855]
ATGTTGGGTTTACCCCAGGAAGAAGAGCGTAGCCGTTTGACCTATGAAGCATTAGCCGATGTAGAGACAGGGCAGGTCAT
TGATTATCAAGCAGTTCAAGCATGGGCGAATAGCCTTAGCACTGATCAAATTTTGCCGTTGCCGCGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A808YAX5