Detailed information of TA system TA206047

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 2735917..2736668
• Replicon: chromosome
• Accession: NZ_CP076605
• Organism: Raoultella ornithinolytica strain XF201

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: KP007_RS13050
• Protein ID: WP_015584327.1
• Coordinates: 2736186..2736668 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A808Y4Y8
• Locus tag: KP007_RS13045
• Protein ID: WP_015584326.1
• Coordinates: 2735917..2736195 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP007_RS13035 (KP007_13035)	2732644..2733192	+	549	WP_226949265.1	DUF4451 domain-containing protein	-
KP007_RS13040 (KP007_13040)	2733350..2735275	-	1926	WP_152308669.1	C1 family peptidase	-
KP007_RS13045 (KP007_13045)	2735917..2736195	+	279	WP_015584326.1	DUF1778 domain-containing protein	Antitoxin
KP007_RS13050 (KP007_13050)	2736186..2736668	+	483	WP_015584327.1	GNAT family N-acetyltransferase	Toxin
KP007_RS26730	2736787..2737162	-	376	Protein_2566	ISNCY family transposase	-
KP007_RS13060 (KP007_13060)	2738201..2739076	-	876	WP_032717451.1	NAD(P)-dependent oxidoreductase	-
KP007_RS13065 (KP007_13065)	2739338..2740054	-	717	WP_004861956.1	ABC transporter ATP-binding protein	-
KP007_RS13070 (KP007_13070)	2740051..2740926	-	876	WP_015584331.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (45-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-92)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17670.56 Da
• Isoelectric Point: 9.7381

>T206047 WP_015584327.1 NZ_CP076605:2736186-2736668 [Raoultella ornithinolytica]
MGMRPPEPLSTGHNIAEFCCQDQVLNEWLKKKALKNHSTGISRVFVVCAENTKRVIAYYSLSSGSVHRNTVPGAYRRNAP
EAVPVIVLGRLAVDAAWVGKGLGAALLKDAIYRTEHIAVQVGVRALLVHALNDEVREFYTRFGFEPSIINTLTLLFPIKV

Nucleotide

• Length: 483 bp

>T206047 NZ_CP102085:1418526-1418834 [Mycoavidus sp. SF9855]
ATGACCGAAAAATTTACTCGATACGATACAGCTGAATATCTGAAAACCGATGAAGATATAGCGGCTTATTTCGATGCTGT
ACTGGAAGAGAATGATCCTCAATTGGCTGTACAAGCGTTGGGTACCATCGCACGCGCTAAAGGAATGAGCCAAATTGCAC
AGGAGACGGGACTTGCCCGCGAAAGTCTATACAGAGCACTTTCTGACACAGGTAACCCGGAATTTGCCACTGTATTTAAA
GTGATCCGTGCGCTTGGCTTACAATTGCACGCCTCACTGCCCCCTATCCAGTATAACGTTGCAGGCTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10714.30 Da
• Isoelectric Point: 4.6722

>AT206047 WP_015584326.1 NZ_CP076605:2735917-2736195 [Raoultella ornithinolytica]
MKPDVREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDKQFASFMEELDAPMTAERQAR
IDNLMNRKSPWE

Nucleotide

• Length: 279 bp

>AT206047 NZ_CP102085:1418224-1418529 [Mycoavidus sp. SF9855]
ATGATTGAAATTATCCAAAGTACGACATTTAGCGCCTGGTTGAGTGATCTGAAGGATCGACAGGCACGAGCGCGTATCCA
AGTGCGGCTTGATCGTATAAGAAATGGAAATTTTGGTGATGTAAAGCCAATTGGTAACGGTTTAAGCGAAGCTCGTATTC
ACTATGGAAATGGTTATCGCCTCTATTTTTTACAGCATAAGAAAGAACTGGTTGTGTTGTTGTGTGGCGGAGATAAAAGC
ACTCAAAGTAGGGATATAGAGCAGGCAAAACGCATTGCACAAGAATGGACGGAGTCAATACTATGA

Structures

Antitoxin

• AlphaFold DB: A0A808Y4Y8