Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2422803..2423716 Replicon chromosome
Accession NZ_CP076605
Organism Raoultella ornithinolytica strain XF201

Toxin (Protein)


Gene name - Uniprot ID A0A808Y4A8
Locus tag KP007_RS11470 Protein ID WP_015584188.1
Coordinates 2422803..2423276 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A808Y7A4
Locus tag KP007_RS11475 Protein ID WP_004862777.1
Coordinates 2423273..2423716 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP007_RS11445 (KP007_11445) 2418842..2419450 - 609 WP_069475887.1 glutathione S-transferase family protein -
KP007_RS11450 (KP007_11450) 2419692..2420597 + 906 WP_004862790.1 transcriptional regulator GcvA -
KP007_RS11455 (KP007_11455) 2420625..2421530 - 906 WP_032716407.1 LysR family transcriptional regulator -
KP007_RS11460 (KP007_11460) 2421633..2421950 + 318 WP_004862785.1 nuclear transport factor 2 family protein -
KP007_RS11465 (KP007_11465) 2421943..2422722 + 780 WP_004862782.1 SDR family oxidoreductase -
KP007_RS11470 (KP007_11470) 2422803..2423276 - 474 WP_015584188.1 RES domain-containing protein Toxin
KP007_RS11475 (KP007_11475) 2423273..2423716 - 444 WP_004862777.1 DUF2384 domain-containing protein Antitoxin
KP007_RS11480 (KP007_11480) 2423906..2424472 - 567 WP_015584190.1 DJ-1/PfpI family protein -
KP007_RS11485 (KP007_11485) 2424869..2425651 + 783 WP_004862772.1 DUF3750 domain-containing protein -
KP007_RS11490 (KP007_11490) 2425847..2427070 + 1224 WP_216711807.1 zinc metallochaperone GTPase ZigA -
KP007_RS11510 (KP007_11510) 2428000..2428533 - 534 WP_088402600.1 acid resistance repetitive basic protein Asr -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17524.82 Da        Isoelectric Point: 4.8081

>T206046 WP_015584188.1 NZ_CP076605:c2423276-2422803 [Raoultella ornithinolytica]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPDSEVESLDKQ
WLPDNWQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL

Download         Length: 474 bp

>T206046 NZ_CP102085:1418224-1418529 [Mycoavidus sp. SF9855]
ATGATTGAAATTATCCAAAGTACGACATTTAGCGCCTGGTTGAGTGATCTGAAGGATCGACAGGCACGAGCGCGTATCCA
AGTGCGGCTTGATCGTATAAGAAATGGAAATTTTGGTGATGTAAAGCCAATTGGTAACGGTTTAAGCGAAGCTCGTATTC
ACTATGGAAATGGTTATCGCCTCTATTTTTTACAGCATAAGAAAGAACTGGTTGTGTTGTTGTGTGGCGGAGATAAAAGC
ACTCAAAGTAGGGATATAGAGCAGGCAAAACGCATTGCACAAGAATGGACGGAGTCAATACTATGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16190.45 Da        Isoelectric Point: 4.9405

>AT206046 WP_004862777.1 NZ_CP076605:c2423716-2423273 [Raoultella ornithinolytica]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSILDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA

Download         Length: 444 bp

>AT206046 NZ_CP102085:1418526-1418834 [Mycoavidus sp. SF9855]
ATGACCGAAAAATTTACTCGATACGATACAGCTGAATATCTGAAAACCGATGAAGATATAGCGGCTTATTTCGATGCTGT
ACTGGAAGAGAATGATCCTCAATTGGCTGTACAAGCGTTGGGTACCATCGCACGCGCTAAAGGAATGAGCCAAATTGCAC
AGGAGACGGGACTTGCCCGCGAAAGTCTATACAGAGCACTTTCTGACACAGGTAACCCGGAATTTGCCACTGTATTTAAA
GTGATCCGTGCGCTTGGCTTACAATTGCACGCCTCACTGCCCCCTATCCAGTATAACGTTGCAGGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808Y4A8

Antitoxin

Source ID Structure
AlphaFold DB A0A808Y7A4

References