Detailed information of TA system TA206037

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 857784..858441
• Replicon: chromosome
• Accession: NZ_CP076605
• Organism: Raoultella ornithinolytica strain XF201

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KP007_RS04175
• Protein ID: WP_088912076.1
• Coordinates: 858031..858441 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A514ELX1
• Locus tag: KP007_RS04170
• Protein ID: WP_004867358.1
• Coordinates: 857784..858050 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP007_RS04145 (KP007_04145)	852918..854351	-	1434	WP_004867372.1	6-phospho-beta-glucosidase	-
KP007_RS04150 (KP007_04150)	854471..855199	-	729	WP_004867368.1	MurR/RpiR family transcriptional regulator	-
KP007_RS04155 (KP007_04155)	855249..855560	+	312	WP_004867365.1	N(4)-acetylcytidine aminohydrolase	-
KP007_RS04160 (KP007_04160)	855722..856381	+	660	WP_004867362.1	hemolysin III family protein	-
KP007_RS04165 (KP007_04165)	856504..857487	-	984	WP_015585783.1	tRNA-modifying protein YgfZ	-
KP007_RS04170 (KP007_04170)	857784..858050	+	267	WP_004867358.1	FAD assembly factor SdhE	Antitoxin
KP007_RS04175 (KP007_04175)	858031..858441	+	411	WP_088912076.1	protein YgfX	Toxin
KP007_RS04180 (KP007_04180)	858449..858970	-	522	WP_004867353.1	flavodoxin FldB	-
KP007_RS04185 (KP007_04185)	859148..860044	+	897	WP_032718225.1	site-specific tyrosine recombinase XerD	-
KP007_RS04190 (KP007_04190)	860067..860780	+	714	WP_004867349.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KP007_RS04195 (KP007_04195)	860786..862519	+	1734	WP_015585785.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16244.19 Da
• Isoelectric Point: 11.3349

>T206037 WP_088912076.1 NZ_CP076605:858031-858441 [Raoultella ornithinolytica]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSMVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDAKEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T206037 NZ_CP102077:c4604649-4604116 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10553.05 Da
• Isoelectric Point: 4.8432

>AT206037 WP_004867358.1 NZ_CP076605:857784-858050 [Raoultella ornithinolytica]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT206037 NZ_CP102077:c4604926-4604660 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A514ELX1