206034

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 22148..22676 Replicon plasmid unnamed
Accession NZ_CP076604
Organism Acinetobacter schindleri strain MCDA01

Toxin (Protein)


Gene name relE Uniprot ID N9NPD1
Locus tag KMZ14_RS15315 Protein ID WP_004897647.1
Coordinates 22383..22676 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9B5Q7
Locus tag KMZ14_RS15310 Protein ID WP_000246756.1
Coordinates 22148..22393 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ14_RS15275 (KMZ14_15215) 17814..18152 + 339 WP_004897649.1 hypothetical protein -
KMZ14_RS15280 (KMZ14_15220) 18139..19083 + 945 WP_104510421.1 copper resistance protein B -
KMZ14_RS15285 (KMZ14_15225) 19236..19538 - 303 WP_001140620.1 XRE family transcriptional regulator -
KMZ14_RS15290 (KMZ14_15230) 19531..19887 - 357 WP_004668307.1 type II toxin-antitoxin system RelE/ParE family toxin -
KMZ14_RS15295 (KMZ14_15235) 20433..20874 - 442 Protein_21 winged helix-turn-helix transcriptional regulator -
KMZ14_RS15300 (KMZ14_15240) 21044..21739 + 696 WP_273799129.1 AzlC family ABC transporter permease -
KMZ14_RS15305 (KMZ14_15245) 21732..22043 + 312 WP_262451135.1 AzlD family protein -
KMZ14_RS15310 (KMZ14_15250) 22148..22393 + 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KMZ14_RS15315 (KMZ14_15255) 22383..22676 + 294 WP_004897647.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KMZ14_RS15320 (KMZ14_15260) 22754..24079 - 1326 WP_273799130.1 ISNCY family transposase -
KMZ14_RS15325 (KMZ14_15265) 24421..25479 - 1059 WP_273799131.1 2,3-butanediol dehydrogenase -
KMZ14_RS15330 (KMZ14_15270) 25501..26286 - 786 WP_273799132.1 acetoin reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..166835 166835
- flank IS/Tn - - 22754..24091 1337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11306.55 Da        Isoelectric Point: 10.4753

>T206034 WP_004897647.1 NZ_CP076604:22383-22676 [Acinetobacter schindleri]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGIRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T206034 NZ_CP102077:2001100-2001202 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9235.61 Da        Isoelectric Point: 4.3142

>AT206034 WP_000246756.1 NZ_CP076604:22148-22393 [Acinetobacter schindleri]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT206034 NZ_CP102077:c2001209-2001064 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9NPD1

Antitoxin

Source ID Structure
AlphaFold DB N9B5Q7

References