Detailed information of TA system TA206032

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 429628..430270
• Replicon: chromosome
• Accession: NZ_CP076603
• Organism: Acinetobacter schindleri strain MCDA01

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KMZ14_RS02135
• Protein ID: WP_273798446.1
• Coordinates: 429878..430270 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: I4ZVX5
• Locus tag: KMZ14_RS02130
• Protein ID: WP_008302635.1
• Coordinates: 429628..429885 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KMZ14_RS02110 (KMZ14_02110)	425099..426106	+	1008	WP_004809777.1	DNA-directed RNA polymerase subunit alpha	-
KMZ14_RS02115 (KMZ14_02115)	426125..426490	+	366	WP_004786886.1	50S ribosomal protein L17	-
KMZ14_RS02120 (KMZ14_02120)	426710..428215	+	1506	WP_273798444.1	NAD(P)/FAD-dependent oxidoreductase	-
KMZ14_RS02125 (KMZ14_02125)	428279..429451	-	1173	WP_273798445.1	acyl-CoA dehydrogenase family protein	-
KMZ14_RS02130 (KMZ14_02130)	429628..429885	+	258	WP_008302635.1	succinate dehydrogenase assembly factor 2	Antitoxin
KMZ14_RS02135 (KMZ14_02135)	429878..430270	+	393	WP_273798446.1	hypothetical protein	Toxin
KMZ14_RS02140 (KMZ14_02140)	430807..431847	+	1041	WP_273798447.1	hypothetical protein	-
KMZ14_RS02145 (KMZ14_02145)	431913..432485	+	573	WP_048881851.1	rhombosortase	-
KMZ14_RS02150 (KMZ14_02150)	432662..434857	+	2196	WP_004809766.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 15733.81 Da
• Isoelectric Point: 10.0025

>T206032 WP_273798446.1 NZ_CP076603:429878-430270 [Acinetobacter schindleri]
MDSHSRCYQLKRSLLALAFQFFIFIVLMFVMYQLLPLWLWGICLVAGLIIYHLFYRKRPQIARFEYLDGREWTITHHDQR
VQRAQISHVIDHQAYLVVYFQHAKVPPLLIWCDQLPTKQWKSLKVLTKMI

Nucleotide

• Length: 393 bp

>T206032 NZ_CP102077:1455853-1456269 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATTATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACCGACATCCGGGTGGCGCTGCACCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCTGGACTGACACTGG
AAGACTGGGTTATTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10254.70 Da
• Isoelectric Point: 4.4898

>AT206032 WP_008302635.1 NZ_CP076603:429628-429885 [Acinetobacter schindleri]
MTEDISLEERKVIYRARRGLKELDVYFDPYVKNCYLTADPFEKEMFAELVAQEDPDLLDWFMEVSEPPRPELREFINKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT206032 NZ_CP102077:1455626-1455856 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Structures

Antitoxin

• AlphaFold DB: A0A1P8PMS5