Detailed information of TA system TA206021

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3025021..3025474
• Replicon: chromosome
• Accession: NZ_CP076595
• Organism: Erwinia amylovora isolate CP20130202

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KQH34_RS13825
• Protein ID: WP_013035888.1
• Coordinates: 3025238..3025474 (+)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4HZA2
• Locus tag: KQH34_RS13820
• Protein ID: WP_004159527.1
• Coordinates: 3025021..3025248 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQH34_RS13810 (KQH34_13795)	3023945..3024349	+	405	WP_013035886.1	hypothetical protein	-
KQH34_RS13815 (KQH34_13800)	3024413..3024700	-	288	WP_004159528.1	SymE family type I addiction module toxin	-
KQH34_RS13820 (KQH34_13805)	3025021..3025248	+	228	WP_004159527.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KQH34_RS13825 (KQH34_13810)	3025238..3025474	+	237	WP_013035888.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQH34_RS13830 (KQH34_13815)	3025461..3025679	-	219	WP_004159522.1	hypothetical protein	-
KQH34_RS13835 (KQH34_13820)	3026007..3028223	+	2217	Protein_2676	ferrichrome porin FhuA	-
KQH34_RS13840 (KQH34_13825)	3028272..3029066	+	795	WP_004159512.1	Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC	-
KQH34_RS13845 (KQH34_13830)	3029081..3029959	+	879	WP_004159509.1	Fe(3+)-hydroxamate ABC transporter substrate-binding protein FhuD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-75)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 9135.79 Da
• Isoelectric Point: 9.0876

>T206021 WP_013035888.1 NZ_CP076595:3025238-3025474 [Erwinia amylovora]
ISYELLFDPWALKEWKKLGATVREQFKKKLAEVLVNLQVESARLRDHPDCCKIKLKSSGYRLVYQVQDEQLVMLVISV

Nucleotide

• Length: 237 bp

>T206021 NZ_CP102070:2481019-2481678 [Enterococcus faecalis]
TTGATTGGACTGTTGTTGGTGGATTTTATTAGTAAAGAACTCTATTTTGAAGCATTTAATTTTTCGAACGAATTAATAAA
AGAAGTATCATACTACTCTTCCAAAAATATTGAACAAGTTAAATGCTTTGATATTGAAAAATATGTAAAAGAAGTTGAAG
ATGTTGAATTTGTTGAATACACGTTTCAAAAACAACTTAAAAGACGGATGCTTGGTTCAATCTCTAAAGTAGACGATGAA
GTCATTATAACAACAAACAAAGAATTAATGTTAGAACGAAAAAATTTCACTAAAATGCATGAGGTTATACATTACTACAT
AGATATACCTAAAATTAATAATGCAACTCATACTTTTTCTGATATTCTTTTAAAAAATGGTTACTTGATGGAAGATTTTC
CAAAAGAATATCGTGCTAATGTTGGTGCTAGCATGTTAATGGCAAATGACCAAGCATTATTTTACGCATTAAAAAAATTT
TATTCATTCGAAGAAATTGCACAATACTTTTTTATGAGCAAATCTGCATTAAGAAATAGACTCATCGAGCATCTTATGTA
TGTAAATAATTGTACTTTTGCACACGCTAATACACTTTTTAACAATTATTACTTTCATAAAAAAACTGATATCTACAGAT
TTATTTTTAATGATTCATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8435.90 Da
• Isoelectric Point: 7.9766

>AT206021 WP_004159527.1 NZ_CP076595:3025021-3025248 [Erwinia amylovora]
VRLDDKLKSKACAVLDELDVSPTEAVRLLFQYIAENERLPLKALTVSDEKDALLKTVRERLASLQKGIKVTLDKL

Nucleotide

• Length: 228 bp

>AT206021 NZ_CP102070:2480636-2481022 [Enterococcus faecalis]
GTGACTATTATTAAAACAAATGAACGTTTGAAACAACTACGTGAAAATAAAGAATTAACTCAAAAAGAATTAGCTGATTT
ACTACACATGGATAGAAGTGTTTATAATAAAATTGAATCAGGTGCTCGTCCCATTCGTGATAACGAACTAATTCAATTTG
CGGATTTCTATAATGTATCAACAGACTACCTTACAAATAGAACTAACAATCCCATTCCCCCTGAAGAAAAAACAAATGTG
GGACAAAATATCATCTCACATTTTCGTCTAAATACTTCTGATATGGACATAGAAGATATAGAAGAATTAGAAGAAGAATT
AATCGACTTTCAAGATTTTCTTATAAAAAAAGCAAAAGAAAAAAAGGAACGTAACAAAAAAGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A831A410