Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1366249..1366915 Replicon chromosome
Accession NZ_CP076595
Organism Erwinia amylovora isolate CP20130202

Toxin (Protein)


Gene name cptA Uniprot ID A0A830ZTB8
Locus tag KQH34_RS06410 Protein ID WP_004161808.1
Coordinates 1366249..1366668 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4HWC2
Locus tag KQH34_RS06415 Protein ID WP_004155593.1
Coordinates 1366649..1366915 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH34_RS06395 (KQH34_06385) 1362241..1363920 + 1680 WP_004155599.1 type III effector -
KQH34_RS06400 (KQH34_06390) 1364430..1365383 + 954 WP_004155597.1 DMT family transporter -
KQH34_RS06405 (KQH34_06395) 1365613..1366131 + 519 WP_004155596.1 flavodoxin FldB -
KQH34_RS06410 (KQH34_06400) 1366249..1366668 - 420 WP_004161808.1 protein YgfX Toxin
KQH34_RS06415 (KQH34_06405) 1366649..1366915 - 267 WP_004155593.1 FAD assembly factor SdhE Antitoxin
KQH34_RS06420 (KQH34_06410) 1367141..1368127 + 987 WP_004155590.1 tRNA-modifying protein YgfZ -
KQH34_RS06425 (KQH34_06415) 1368128..1368787 - 660 WP_004155588.1 hemolysin III family protein -
KQH34_RS06430 (KQH34_06420) 1369000..1369608 + 609 WP_004155587.1 HD domain-containing protein -
KQH34_RS06435 (KQH34_06425) 1369713..1370442 - 730 Protein_1243 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16366.46 Da        Isoelectric Point: 11.9444

>T206015 WP_004161808.1 NZ_CP076595:c1366668-1366249 [Erwinia amylovora]
VVLWQCELRPSRLAQRFSLLLHGAVMLALLLPTWPASSGLVRMLLLVLVLLECIRSRRRIGRRQGDIALLEGHELRWRQR
EWCIISRPWLTGQAILLLLQDTHGQRERLWLFADGMEKRNWRQLRLQLLNSKVQGNGWC

Download         Length: 420 bp

>T206015 NZ_CP102065:2697945-2698088 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10498.07 Da        Isoelectric Point: 6.4605

>AT206015 WP_004155593.1 NZ_CP076595:c1366915-1366649 [Erwinia amylovora]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDSDKRLFVRLLESDDPDLFNWLMNHGEPADVELKRMVALIQQRN
KQRGPVAM

Download         Length: 267 bp

>AT206015 NZ_CP102065:c2698282-2698020 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A830ZTB8

Antitoxin

Source ID Structure
AlphaFold DB A0A831A3F0

References