Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1007895..1008522 Replicon chromosome
Accession NZ_CP076595
Organism Erwinia amylovora isolate CP20130202

Toxin (Protein)


Gene name Hha Uniprot ID D2T444
Locus tag KQH34_RS04735 Protein ID WP_004156337.1
Coordinates 1008304..1008522 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag KQH34_RS04730 Protein ID WP_013035913.1
Coordinates 1007895..1008284 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH34_RS04710 (KQH34_04695) 1002914..1006060 + 3147 WP_004161886.1 multidrug efflux RND transporter permease subunit AcrB -
KQH34_RS04715 (KQH34_04700) 1006208..1006489 + 282 WP_004156350.1 type B 50S ribosomal protein L31 -
KQH34_RS04720 (KQH34_04705) 1006477..1006623 + 147 WP_004156349.1 type B 50S ribosomal protein L36 -
KQH34_RS04725 (KQH34_04710) 1007395..1007748 + 354 WP_004156342.1 hypothetical protein -
KQH34_RS04730 (KQH34_04715) 1007895..1008284 + 390 WP_013035913.1 Hha toxicity modulator TomB Antitoxin
KQH34_RS04735 (KQH34_04720) 1008304..1008522 + 219 WP_004156337.1 HHA domain-containing protein Toxin
KQH34_RS04745 (KQH34_04730) 1008822..1009139 + 318 WP_004156334.1 MGMT family protein -
KQH34_RS04750 (KQH34_04735) 1009162..1009719 - 558 WP_004156333.1 YbaY family lipoprotein -
KQH34_RS04755 (KQH34_04740) 1009944..1010804 + 861 WP_004156324.1 acyl-CoA thioesterase II -
KQH34_RS04760 (KQH34_04745) 1010879..1012180 - 1302 WP_004172214.1 ammonium transporter AmtB -
KQH34_RS04765 (KQH34_04750) 1012198..1012536 - 339 WP_004156319.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8627.06 Da        Isoelectric Point: 8.9007

>T206014 WP_004156337.1 NZ_CP076595:1008304-1008522 [Erwinia amylovora]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Download         Length: 219 bp

>T206014 NZ_CP102065:2697945-2698088 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14965.70 Da        Isoelectric Point: 4.7040

>AT206014 WP_013035913.1 NZ_CP076595:1007895-1008284 [Erwinia amylovora]
MDEYSPKRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSTSNLQLNDLIEHIAAFTMNYKIKHIEDSDLISQIDEYL
DDTFMLFSNYGVNNLDLQRWQKSAKRLFNIFAKECVMSQIQSSHSFSSP

Download         Length: 390 bp

>AT206014 NZ_CP102065:c2697834-2697759 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPQ0

Antitoxin

Source ID Structure

References