Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2505310..2505937 Replicon chromosome
Accession NZ_CP076594
Organism Erwinia amylovora isolate CP20086202

Toxin (Protein)


Gene name Hha Uniprot ID D2T444
Locus tag KQH36_RS11355 Protein ID WP_004156337.1
Coordinates 2505719..2505937 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag KQH36_RS11350 Protein ID WP_013035913.1
Coordinates 2505310..2505699 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH36_RS11330 (KQH36_11325) 2500329..2503475 + 3147 WP_004161886.1 multidrug efflux RND transporter permease subunit AcrB -
KQH36_RS11335 (KQH36_11330) 2503623..2503904 + 282 WP_004156350.1 type B 50S ribosomal protein L31 -
KQH36_RS11340 (KQH36_11335) 2503892..2504038 + 147 WP_004156349.1 type B 50S ribosomal protein L36 -
KQH36_RS11345 (KQH36_11340) 2504810..2505163 + 354 WP_004156342.1 hypothetical protein -
KQH36_RS11350 (KQH36_11345) 2505310..2505699 + 390 WP_013035913.1 Hha toxicity modulator TomB Antitoxin
KQH36_RS11355 (KQH36_11350) 2505719..2505937 + 219 WP_004156337.1 HHA domain-containing protein Toxin
KQH36_RS11365 (KQH36_11360) 2506237..2506554 + 318 WP_004156334.1 MGMT family protein -
KQH36_RS11370 (KQH36_11365) 2506577..2507134 - 558 WP_004156333.1 YbaY family lipoprotein -
KQH36_RS11375 (KQH36_11370) 2507359..2508219 + 861 WP_004156324.1 acyl-CoA thioesterase II -
KQH36_RS11380 (KQH36_11375) 2508294..2509595 - 1302 WP_004172214.1 ammonium transporter AmtB -
KQH36_RS11385 (KQH36_11380) 2509613..2509951 - 339 WP_004156319.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8627.06 Da        Isoelectric Point: 8.9007

>T206008 WP_004156337.1 NZ_CP076594:2505719-2505937 [Erwinia amylovora]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Download         Length: 219 bp

>T206008 NZ_CP102065:c305150-305055 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14965.70 Da        Isoelectric Point: 4.7040

>AT206008 WP_013035913.1 NZ_CP076594:2505310-2505699 [Erwinia amylovora]
MDEYSPKRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSTSNLQLNDLIEHIAAFTMNYKIKHIEDSDLISQIDEYL
DDTFMLFSNYGVNNLDLQRWQKSAKRLFNIFAKECVMSQIQSSHSFSSP

Download         Length: 390 bp

>AT206008 NZ_CP102065:304955-305020 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPQ0

Antitoxin

Source ID Structure

References