Detailed information of TA system TA206005

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 718369..718822
• Replicon: chromosome
• Accession: NZ_CP076594
• Organism: Erwinia amylovora isolate CP20086202

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KQH36_RS03190
• Protein ID: WP_013035888.1
• Coordinates: 718586..718822 (+)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4HZA2
• Locus tag: KQH36_RS03185
• Protein ID: WP_004159527.1
• Coordinates: 718369..718596 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQH36_RS03175 (KQH36_03165)	717293..717697	+	405	WP_013035886.1	hypothetical protein	-
KQH36_RS03180 (KQH36_03170)	717761..718048	-	288	WP_004159528.1	SymE family type I addiction module toxin	-
KQH36_RS03185 (KQH36_03175)	718369..718596	+	228	WP_004159527.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KQH36_RS03190 (KQH36_03180)	718586..718822	+	237	WP_013035888.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQH36_RS03195 (KQH36_03185)	718809..719027	-	219	WP_004159522.1	hypothetical protein	-
KQH36_RS03200 (KQH36_03190)	719355..721571	+	2217	Protein_610	ferrichrome porin FhuA	-
KQH36_RS03205 (KQH36_03195)	721620..722414	+	795	WP_004159512.1	Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC	-
KQH36_RS03210 (KQH36_03200)	722429..723307	+	879	WP_004159509.1	Fe(3+)-hydroxamate ABC transporter substrate-binding protein FhuD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-75)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 9135.79 Da
• Isoelectric Point: 9.0876

>T206005 WP_013035888.1 NZ_CP076594:718586-718822 [Erwinia amylovora]
ISYELLFDPWALKEWKKLGATVREQFKKKLAEVLVNLQVESARLRDHPDCCKIKLKSSGYRLVYQVQDEQLVMLVISV

Nucleotide

• Length: 237 bp

>T206005 NZ_CP102061:c4187043-4186825 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8435.90 Da
• Isoelectric Point: 7.9766

>AT206005 WP_004159527.1 NZ_CP076594:718369-718596 [Erwinia amylovora]
VRLDDKLKSKACAVLDELDVSPTEAVRLLFQYIAENERLPLKALTVSDEKDALLKTVRERLASLQKGIKVTLDKL

Nucleotide

• Length: 228 bp

>AT206005 NZ_CP102061:c4187443-4187069 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A831A410