Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 3754528..3755140 | Replicon | chromosome |
| Accession | NZ_CP076592 | ||
| Organism | Erwinia amylovora isolate CP20140001 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | D2TUP9 |
| Locus tag | KQH33_RS17020 | Protein ID | WP_012906750.1 |
| Coordinates | 3754528..3754707 (+) | Length | 60 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | D4I356 |
| Locus tag | KQH33_RS17025 | Protein ID | WP_004157632.1 |
| Coordinates | 3754730..3755140 (+) | Length | 137 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KQH33_RS17000 (KQH33_17010) | 3750086..3751036 | + | 951 | WP_004157624.1 | DUF1471 family protein YdgH | - |
| KQH33_RS17005 (KQH33_17015) | 3751244..3752635 | + | 1392 | WP_004157625.1 | amino acid permease | - |
| KQH33_RS17010 (KQH33_17020) | 3752639..3753103 | - | 465 | WP_004157626.1 | hypothetical protein | - |
| KQH33_RS17015 (KQH33_17025) | 3753280..3754008 | + | 729 | WP_004157629.1 | two-component system response regulator RstA | - |
| KQH33_RS17020 (KQH33_17030) | 3754528..3754707 | + | 180 | WP_012906750.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KQH33_RS17025 (KQH33_17035) | 3754730..3755140 | + | 411 | WP_004157632.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KQH33_RS17030 (KQH33_17040) | 3755196..3756197 | + | 1002 | WP_004157633.1 | acyltransferase | - |
| KQH33_RS17035 (KQH33_17045) | 3757068..3757280 | - | 213 | WP_004157635.1 | hypothetical protein | - |
| KQH33_RS17040 (KQH33_17050) | 3757538..3757711 | - | 174 | WP_004157636.1 | hypothetical protein | - |
| KQH33_RS17045 (KQH33_17055) | 3757806..3757979 | - | 174 | WP_013036045.1 | hypothetical protein | - |
| KQH33_RS17050 (KQH33_17060) | 3757990..3758262 | - | 273 | WP_004157637.1 | hypothetical protein | - |
| KQH33_RS17055 (KQH33_17065) | 3758892..3759482 | + | 591 | WP_223386180.1 | DapH/DapD/GlmU-related protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3748366..3759482 | 11116 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6644.85 Da Isoelectric Point: 10.9132
>T206001 WP_012906750.1 NZ_CP076592:3754528-3754707 [Erwinia amylovora]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL
Download Length: 180 bp
>T206001 NZ_CP102061:3545362-3545739 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 137 a.a. Molecular weight: 14829.76 Da Isoelectric Point: 4.3623
>AT206001 WP_004157632.1 NZ_CP076592:3754730-3755140 [Erwinia amylovora]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR
Download Length: 411 bp
>AT206001 NZ_CP102061:3544904-3545272 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7D6XDK4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A830ZVY0 |