Detailed information of TA system TA205991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3404532..3404985
• Replicon: chromosome
• Accession: NZ_CP076591
• Organism: Erwinia amylovora isolate CP201142

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KQH37_RS15445
• Protein ID: WP_013035888.1
• Coordinates: 3404749..3404985 (+)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4HZA2
• Locus tag: KQH37_RS15440
• Protein ID: WP_004159527.1
• Coordinates: 3404532..3404759 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQH37_RS15430 (KQH37_15430)	3403456..3403860	+	405	WP_013035886.1	hypothetical protein	-
KQH37_RS15435 (KQH37_15435)	3403924..3404211	-	288	WP_004159528.1	SymE family type I addiction module toxin	-
KQH37_RS15440 (KQH37_15440)	3404532..3404759	+	228	WP_004159527.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KQH37_RS15445 (KQH37_15445)	3404749..3404985	+	237	WP_013035888.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQH37_RS15450 (KQH37_15450)	3404972..3405190	-	219	WP_004159522.1	hypothetical protein	-
KQH37_RS15455 (KQH37_15455)	3405518..3407734	+	2217	Protein_2995	ferrichrome porin FhuA	-
KQH37_RS15460 (KQH37_15460)	3407783..3408577	+	795	WP_004159512.1	Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC	-
KQH37_RS15465 (KQH37_15465)	3408592..3409470	+	879	WP_004159509.1	Fe(3+)-hydroxamate ABC transporter substrate-binding protein FhuD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-75)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 9135.79 Da
• Isoelectric Point: 9.0876

>T205991 WP_013035888.1 NZ_CP076591:3404749-3404985 [Erwinia amylovora]
ISYELLFDPWALKEWKKLGATVREQFKKKLAEVLVNLQVESARLRDHPDCCKIKLKSSGYRLVYQVQDEQLVMLVISV

Nucleotide

• Length: 237 bp

>T205991 NZ_CP102061:c1789746-1789339 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8435.90 Da
• Isoelectric Point: 7.9766

>AT205991 WP_004159527.1 NZ_CP076591:3404532-3404759 [Erwinia amylovora]
VRLDDKLKSKACAVLDELDVSPTEAVRLLFQYIAENERLPLKALTVSDEKDALLKTVRERLASLQKGIKVTLDKL

Nucleotide

• Length: 228 bp

>AT205991 NZ_CP102061:c1789993-1789727 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A831A410