Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1745803..1746469 Replicon chromosome
Accession NZ_CP076591
Organism Erwinia amylovora isolate CP201142

Toxin (Protein)


Gene name cptA Uniprot ID A0A830ZTB8
Locus tag KQH37_RS08035 Protein ID WP_004161808.1
Coordinates 1745803..1746222 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4HWC2
Locus tag KQH37_RS08040 Protein ID WP_004155593.1
Coordinates 1746203..1746469 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH37_RS08020 (KQH37_08030) 1741795..1743474 + 1680 WP_004155599.1 type III effector -
KQH37_RS08025 (KQH37_08035) 1743984..1744937 + 954 WP_004155597.1 DMT family transporter -
KQH37_RS08030 (KQH37_08040) 1745167..1745685 + 519 WP_004155596.1 flavodoxin FldB -
KQH37_RS08035 (KQH37_08045) 1745803..1746222 - 420 WP_004161808.1 protein YgfX Toxin
KQH37_RS08040 (KQH37_08050) 1746203..1746469 - 267 WP_004155593.1 FAD assembly factor SdhE Antitoxin
KQH37_RS08045 (KQH37_08055) 1746695..1747681 + 987 WP_004155590.1 tRNA-modifying protein YgfZ -
KQH37_RS08050 (KQH37_08060) 1747682..1748341 - 660 WP_004155588.1 hemolysin III family protein -
KQH37_RS08055 (KQH37_08065) 1748554..1749162 + 609 WP_004155587.1 HD domain-containing protein -
KQH37_RS08060 (KQH37_08070) 1749267..1749996 - 730 Protein_1562 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16366.46 Da        Isoelectric Point: 11.9444

>T205985 WP_004161808.1 NZ_CP076591:c1746222-1745803 [Erwinia amylovora]
VVLWQCELRPSRLAQRFSLLLHGAVMLALLLPTWPASSGLVRMLLLVLVLLECIRSRRRIGRRQGDIALLEGHELRWRQR
EWCIISRPWLTGQAILLLLQDTHGQRERLWLFADGMEKRNWRQLRLQLLNSKVQGNGWC

Download         Length: 420 bp

>T205985 NZ_CP101990:746992-747411 [Aeromicrobium sp. zg.Y50]
ATGATCGTGCTCGACACGAACGTCATCTCGGAGATCTTCCGTCCACAGCCTGAGCCGCGCGTGCTGGCGTGGCTCGAGTC
GCTCACCGACGACGTCGCCATCACCTCGATCACGCTTGCGGAGCTACTCGCCGGAGTCCACAGGCTCCCGGAGGGTCGAC
GCACGACGGATCTCGCGGCAGCGATCCATGCCGCGATCCAGCCGTACCGGGACACGCGTTCACTGCTTGCCTTCGACGAG
GATGCTGCCGCTGAGTACGCCGAGGTGGTCGTCTCGCGCGAGCGCGCCGGGCTGCCGATCAGCATGGTCGATGCCCAGAT
TGCCGCGATCTGCCGCGTGAACCGGGCGATTTGCGCCACCCGGAACGTGAAGGACTTCGAGGCCACCGGCGTTGACGTCG
CCAACCCTTGGCGTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10498.07 Da        Isoelectric Point: 6.4605

>AT205985 WP_004155593.1 NZ_CP076591:c1746469-1746203 [Erwinia amylovora]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDSDKRLFVRLLESDDPDLFNWLMNHGEPADVELKRMVALIQQRN
KQRGPVAM

Download         Length: 267 bp

>AT205985 NZ_CP101990:746762-746995 [Aeromicrobium sp. zg.Y50]
ATGGCGTCCATCATCGTCAGAGGGCTCGATGATTCGGTGAAGCAGCGGCTCGCCGCACAGGCCGAAGAGCACGGCCGGTC
GATGGAGGCCGAGGTGCGGGACATCCTCACGCGTGCGGCGTCGCGTCCCCATGTCGGGCTCGCCCTCCTGGAGGTCGCTC
GTGCAGTCGGGGGCGTTGAGGATCTTGCGATCCCTGACCGCGCTGATGCGGCTCGCGGGGTGGACTTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A830ZTB8

Antitoxin

Source ID Structure
AlphaFold DB A0A831A3F0

References