Detailed information of TA system TA205984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1387450..1388077
• Replicon: chromosome
• Accession: NZ_CP076591
• Organism: Erwinia amylovora isolate CP201142

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: D2T444
• Locus tag: KQH37_RS06360
• Protein ID: WP_004156337.1
• Coordinates: 1387859..1388077 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: KQH37_RS06355
• Protein ID: WP_013035913.1
• Coordinates: 1387450..1387839 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQH37_RS06335 (KQH37_06340)	1382469..1385615	+	3147	WP_004161886.1	multidrug efflux RND transporter permease subunit AcrB	-
KQH37_RS06340 (KQH37_06345)	1385763..1386044	+	282	WP_004156350.1	type B 50S ribosomal protein L31	-
KQH37_RS06345 (KQH37_06350)	1386032..1386178	+	147	WP_004156349.1	type B 50S ribosomal protein L36	-
KQH37_RS06350 (KQH37_06355)	1386950..1387303	+	354	WP_004156342.1	hypothetical protein	-
KQH37_RS06355 (KQH37_06360)	1387450..1387839	+	390	WP_013035913.1	Hha toxicity modulator TomB	Antitoxin
KQH37_RS06360 (KQH37_06365)	1387859..1388077	+	219	WP_004156337.1	HHA domain-containing protein	Toxin
KQH37_RS06370 (KQH37_06375)	1388377..1388694	+	318	WP_004156334.1	MGMT family protein	-
KQH37_RS06375 (KQH37_06380)	1388717..1389274	-	558	WP_004156333.1	YbaY family lipoprotein	-
KQH37_RS06380 (KQH37_06385)	1389499..1390359	+	861	WP_004156324.1	acyl-CoA thioesterase II	-
KQH37_RS06385 (KQH37_06390)	1390434..1391735	-	1302	WP_004172214.1	ammonium transporter AmtB	-
KQH37_RS06390 (KQH37_06395)	1391753..1392091	-	339	WP_004156319.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8627.06 Da
• Isoelectric Point: 8.9007

>T205984 WP_004156337.1 NZ_CP076591:1387859-1388077 [Erwinia amylovora]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Nucleotide

• Length: 219 bp

>T205984 NZ_CP101989:c3814321-3813929 [Cellulomonas wangsupingiae]
GTGGCGTACTACCTGGACACCTCGGCACTGGTGAAGCTCGTCGTCGAGGAGGCGGAGACGCCGGCGCTGCGGGAGTGGTG
GCGGTCGCACGGCACCACTCCGGTCGCATGCGACCTGGTGCGCACCGAGCTGATGCGCGCCGTCCGCCGGGCTGCGCCCG
AGGCTGCGGTGCAGGCGCACGCGGTGCTCGACGGGCTAGTGCTGCTGTCGGTGACGTCGCGGGTGTGCGACGCGGCAGGG
CGTCTGGAGCCCGCGACGCTGCGGTCGTTGGATGCGATCCACCTGGCCGCCGCGCTCGAGCTCGGCGACGACCTGGAGGG
GATCGTGACGTACGACGACCGGCTCGCGGAGGCGGCGGTGGCGTACGGGGTTGCGGTGGTGGCGCCGGCCTGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14965.70 Da
• Isoelectric Point: 4.7040

>AT205984 WP_013035913.1 NZ_CP076591:1387450-1387839 [Erwinia amylovora]
MDEYSPKRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSTSNLQLNDLIEHIAAFTMNYKIKHIEDSDLISQIDEYL
DDTFMLFSNYGVNNLDLQRWQKSAKRLFNIFAKECVMSQIQSSHSFSSP

Nucleotide

• Length: 390 bp

>AT205984 NZ_CP101989:c3814596-3814324 [Cellulomonas wangsupingiae]
ATGGCGACCATCGGTATCCGCGAGCTGAAGCAGAACGCCTCCGCGGCGGTCGCGCGCGCGGCGTCCGGCGAGACCCTGAC
CGTGACTGATCGGGGCCGGCCCACGGCGCAGCTCTCGCCGTTGCCGTCGTCGCCCCTGGCGCGTCTGCTCACGAGCGGGG
CCGCGCGTCCGGCGCGTACCGATCTGGCCGCGCTTCCGGAGCCCCGTCCTGCGGCGGGCGGACGGCCCTCGCTGTCCGAC
GCGCTCGCCGAGCTGCGCGCCGACGAGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A831EPQ0