Detailed information of TA system TA205978

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2645498..2645951
• Replicon: chromosome
• Accession: NZ_CP076590
• Organism: Erwinia amylovora isolate CP200930

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KQH39_RS12220
• Protein ID: WP_013035888.1
• Coordinates: 2645498..2645734 (-)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4HZA2
• Locus tag: KQH39_RS12225
• Protein ID: WP_004159527.1
• Coordinates: 2645724..2645951 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQH39_RS12200 (KQH39_12220)	2641013..2641891	-	879	WP_004159509.1	Fe(3+)-hydroxamate ABC transporter substrate-binding protein FhuD	-
KQH39_RS12205 (KQH39_12225)	2641906..2642700	-	795	WP_004159512.1	Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC	-
KQH39_RS12210 (KQH39_12230)	2642749..2644965	-	2217	Protein_2366	ferrichrome porin FhuA	-
KQH39_RS12215 (KQH39_12235)	2645293..2645511	+	219	WP_004159522.1	hypothetical protein	-
KQH39_RS12220 (KQH39_12240)	2645498..2645734	-	237	WP_013035888.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQH39_RS12225 (KQH39_12245)	2645724..2645951	-	228	WP_004159527.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KQH39_RS12230 (KQH39_12250)	2646272..2646559	+	288	WP_004159528.1	SymE family type I addiction module toxin	-
KQH39_RS12235 (KQH39_12255)	2646623..2647027	-	405	WP_013035886.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-75)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 9135.79 Da
• Isoelectric Point: 9.0876

>T205978 WP_013035888.1 NZ_CP076590:c2645734-2645498 [Erwinia amylovora]
ISYELLFDPWALKEWKKLGATVREQFKKKLAEVLVNLQVESARLRDHPDCCKIKLKSSGYRLVYQVQDEQLVMLVISV

Nucleotide

• Length: 237 bp

>T205978 NZ_CP101986:155701-156216 [Streptococcus mutans]
ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGCGTCTTTGTCTGTAGCAGTATCTTAAACGATGCTTATTTCACAGCAAGAAAAAACAAAAAATTCCT
CTATGTGTATGCCGTTATTATTGCTATTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8435.90 Da
• Isoelectric Point: 7.9766

>AT205978 WP_004159527.1 NZ_CP076590:c2645951-2645724 [Erwinia amylovora]
VRLDDKLKSKACAVLDELDVSPTEAVRLLFQYIAENERLPLKALTVSDEKDALLKTVRERLASLQKGIKVTLDKL

Nucleotide

• Length: 228 bp

>AT205978 NZ_CP101986:156216-156662 [Streptococcus mutans]
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACTTTTGGAAAGACTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTTGGTCCTTTTGTTGATCCACGTTTTGGAAAAATTGCAAAA
ATCGGTCGTTTGGCCGCTGTTCCCCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTATCGTCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A831A410