Detailed information of TA system TA205975

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 858481..859108
• Replicon: chromosome
• Accession: NZ_CP076590
• Organism: Erwinia amylovora isolate CP200930

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: D2T444
• Locus tag: KQH39_RS04050
• Protein ID: WP_004156337.1
• Coordinates: 858481..858699 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: KQH39_RS04055
• Protein ID: WP_013035913.1
• Coordinates: 858719..859108 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQH39_RS04020 (KQH39_04035)	854467..854805	+	339	WP_004156319.1	P-II family nitrogen regulator	-
KQH39_RS04025 (KQH39_04040)	854823..856124	+	1302	WP_004172214.1	ammonium transporter AmtB	-
KQH39_RS04030 (KQH39_04045)	856199..857059	-	861	WP_004156324.1	acyl-CoA thioesterase II	-
KQH39_RS04035 (KQH39_04050)	857284..857841	+	558	WP_004156333.1	YbaY family lipoprotein	-
KQH39_RS04040 (KQH39_04055)	857864..858181	-	318	WP_004156334.1	MGMT family protein	-
KQH39_RS04050 (KQH39_04065)	858481..858699	-	219	WP_004156337.1	HHA domain-containing protein	Toxin
KQH39_RS04055 (KQH39_04070)	858719..859108	-	390	WP_013035913.1	Hha toxicity modulator TomB	Antitoxin
KQH39_RS04060 (KQH39_04075)	859255..859608	-	354	WP_004156342.1	hypothetical protein	-
KQH39_RS04065 (KQH39_04080)	860380..860526	-	147	WP_004156349.1	type B 50S ribosomal protein L36	-
KQH39_RS04070 (KQH39_04085)	860514..860795	-	282	WP_004156350.1	type B 50S ribosomal protein L31	-
KQH39_RS04075 (KQH39_04090)	860943..864089	-	3147	WP_004161886.1	multidrug efflux RND transporter permease subunit AcrB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8627.06 Da
• Isoelectric Point: 8.9007

>T205975 WP_004156337.1 NZ_CP076590:c858699-858481 [Erwinia amylovora]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Nucleotide

• Length: 219 bp

>T205975 NZ_CP101985:165647-165979 [Streptococcus mutans]
GTGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAACCATAGTATCGTAACCAAGTATTCTAATATTGCTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTACCCTTTTTATGTTCCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATCGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAGGTGCTATT
TGAAAAAGGATAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14965.70 Da
• Isoelectric Point: 4.7040

>AT205975 WP_013035913.1 NZ_CP076590:c859108-858719 [Erwinia amylovora]
MDEYSPKRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSTSNLQLNDLIEHIAAFTMNYKIKHIEDSDLISQIDEYL
DDTFMLFSNYGVNNLDLQRWQKSAKRLFNIFAKECVMSQIQSSHSFSSP

Nucleotide

• Length: 390 bp

>AT205975 NZ_CP101985:165408-165653 [Streptococcus mutans]
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATGTCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGTTCTATTTGAAAGCGTGGGAAATGAACAG
TGGTAA

Structures

Toxin

• AlphaFold DB: A0A831EPQ0