205974

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 500091..500757 Replicon chromosome
Accession NZ_CP076590
Organism Erwinia amylovora isolate CP200930

Toxin (Protein)


Gene name cptA Uniprot ID A0A830ZTB8
Locus tag KQH39_RS02375 Protein ID WP_004161808.1
Coordinates 500338..500757 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4HWC2
Locus tag KQH39_RS02370 Protein ID WP_004155593.1
Coordinates 500091..500357 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH39_RS02350 (KQH39_02360) 496564..497293 + 730 Protein_459 SDR family oxidoreductase -
KQH39_RS02355 (KQH39_02365) 497398..498006 - 609 WP_004155587.1 HD domain-containing protein -
KQH39_RS02360 (KQH39_02370) 498219..498878 + 660 WP_004155588.1 hemolysin III family protein -
KQH39_RS02365 (KQH39_02375) 498879..499865 - 987 WP_004155590.1 tRNA-modifying protein YgfZ -
KQH39_RS02370 (KQH39_02380) 500091..500357 + 267 WP_004155593.1 FAD assembly factor SdhE Antitoxin
KQH39_RS02375 (KQH39_02385) 500338..500757 + 420 WP_004161808.1 protein YgfX Toxin
KQH39_RS02380 (KQH39_02390) 500875..501393 - 519 WP_004155596.1 flavodoxin FldB -
KQH39_RS02385 (KQH39_02395) 501623..502576 - 954 WP_004155597.1 DMT family transporter -
KQH39_RS02390 (KQH39_02400) 503086..504765 - 1680 WP_004155599.1 type III effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16366.46 Da        Isoelectric Point: 11.9444

>T205974 WP_004161808.1 NZ_CP076590:500338-500757 [Erwinia amylovora]
VVLWQCELRPSRLAQRFSLLLHGAVMLALLLPTWPASSGLVRMLLLVLVLLECIRSRRRIGRRQGDIALLEGHELRWRQR
EWCIISRPWLTGQAILLLLQDTHGQRERLWLFADGMEKRNWRQLRLQLLNSKVQGNGWC

Download         Length: 420 bp

>T205974 NZ_CP101985:155701-156216 [Streptococcus mutans]
ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGCGTCTTTGTCTGTAGCAGTATCTTAAACGATGCTTATTTCACAGCAAGAAAAAACAAAAAATTCCT
CTATGTGTATGCCGTTATTATTGCTATTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10498.07 Da        Isoelectric Point: 6.4605

>AT205974 WP_004155593.1 NZ_CP076590:500091-500357 [Erwinia amylovora]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDSDKRLFVRLLESDDPDLFNWLMNHGEPADVELKRMVALIQQRN
KQRGPVAM

Download         Length: 267 bp

>AT205974 NZ_CP101985:156216-156662 [Streptococcus mutans]
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACTTTTGGAAAGACTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTTGGTCCTTTTGTTGATCCACGTTTTGGAAAAATTGCAAAA
ATCGGTCGTTTGGCCGCTGTTCCCCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTATCGTCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A830ZTB8

Antitoxin

Source ID Structure
AlphaFold DB A0A831A3F0

References